Ribosomal protein S6 kinase alpha-4

NameRibosomal protein S6 kinase alpha-4
Synonyms
  • 2.7.11.1
  • 90 kDa ribosomal protein S6 kinase 4
  • MSK2
  • Nuclear mitogen- and stress-activated protein kinase 2
  • Ribosomal protein kinase B
  • RSKB
  • S6K-alpha-4
Gene NameRPS6KA4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009533|Ribosomal protein S6 kinase alpha-4
MGDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGK
LYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSG
GEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDF
GLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTL
EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF
FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYS
FVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQG
SFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTY
LVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYAD
DTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILY
MMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPA
KRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLK
SVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAPRRANGPLPPS
Number of residuesNone
Molecular Weight85605.025
Theoretical pINone
GO Classification
Functions
  • ATP binding
  • protein serine/threonine kinase activity
  • magnesium ion binding
  • mitogen-activated protein kinase p38 binding
  • histone kinase activity (H3-S10 specific)
  • ribosomal protein S6 kinase activity
Processes
  • histone H3-S10 phosphorylation
  • intracellular signal transduction
  • histone H3-S28 phosphorylation
  • positive regulation of CREB transcription factor activity
  • negative regulation of cytokine production
  • positive regulation of NF-kappaB transcription factor activity
  • positive regulation of histone acetylation
  • inflammatory response
  • positive regulation of histone phosphorylation
  • histone phosphorylation
  • interleukin-1-mediated signaling pathway
  • axon guidance
  • regulation of transcription, DNA-templated
  • positive regulation of transcription from RNA polymerase II promoter
  • protein phosphorylation
Components
  • cytoplasm
  • nucleus
  • nucleoplasm
General FunctionRibosomal protein s6 kinase activity
Specific FunctionSerine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDO75676
UniProtKB Entry Name
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013218|Ribosomal protein S6 kinase alpha-4 (RPS6KA4)
ATGGGGGACGAGGACGACGATGAGAGCTGCGCCGTGGAGCTGCGGATCACAGAAGCCAAC
CTGACCGGGCACGAGGAGAAGGTGAGCGTGGAGAACTTCGAGCTGCTCAAGGTGCTGGGC
ACGGGAGCCTACGGCAAGGTGTTCCTGGTGCGGAAGGCGGGCGGGCACGACGCGGGGAAG
CTGTACGCCATGAAGGTGCTGCGCAAGGCGGCGCTGGTGCAGCGCGCCAAGACGCAAGAG
CACACGCGCACCGAGCGCTCGGTGCTGGAGCTGGTGCGCCAGGCGCCCTTCCTGGTCACG
CTGCACTACGCTTTCCAGACGGATGCCAAGCTGCACCTCATCCTGGACTATGTGAGCGGC
GGGGAGATGTTCACCCACCTCTACCAGCGCCAGTACTTCAAGGAGGCTGAGGTGCGCGTG
TATGGGGGTGAGATCGTGCTGGCCCTGGAACACCTGCACAAGCTCGGCATCATTTACCGA
GACCTGAAACTGGAGAATGTGCTGCTGGACTCCGAGGGCCACATTGTCCTCACGGACTTC
GGGCTGAGCAAGGAGTTCCTGACGGAGGAGAAAGAGCGGACCTTCTCCTTCTGTGGCACC
ATCGAGTACATGGCCCCCGAAATCATCCGTAGCAAGACGGGGCATGGCAAGGCTGTGGAC
TGGTGGAGCCTGGGCATCTTGCTCTTCGAGCTGCTGACGGGGGCCTCGCCCTTCACCCTG
GAGGGCGAGAGGAACACGCAGGCTGAGGTGTCTCGACGGATCCTGAAGTGCTCCCCTCCC
TTCCCCCCTCGGATCGGGCCCGTGGCGCAGGACCTGCTGCAGCGGCTGCTTTGTAAGGAT
CCTAAGAAGCGATTGGGCGCGGGGCCCCAGGGGGCACAAGAAGTCCGGAACCATCCCTTC
TTCCAGGGCCTCGATTGGGTGGCTCTGGCTGCCAGGAAGATTCCAGCCCCATTCCGGCCC
CAAATCCGCTCAGAGCTGGATGTGGGCAACTTTGCGGAGGAATTCACTCGGCTGGAGCCT
GTCTACTCACCCCCTGGCAGCCCCCCACCTGGGGACCCCCGAATCTTTCAGGGATACTCC
TTTGTGGCACCCTCCATTCTCTTTGACCACAACAACGCGGTGATGACCGATGGGCTGGAA
GCGCCTGGTGCTGGAGACCGGCCAGGTCGGGCAGCGGTGGCCAGGAGCGCTATGATGCAG
CAGTACGAGCTGGACCTGCGGGAGCCTGCGCTGGGCCAGGGCAGCTTTTCTGTGTGTCGC
CGCTGCCGCCAGCGCCAGAGCGGCCAGGAGTTCGCAGTCAAGATCCTCAGTCGCAGGCTG
GAGGCGAACACGCAGCGCGAAGTGGCTGCCCTGCGCCTGTGCCAGTCACACCCCAACGTG
GTGAATCTGCACGAGGTGCATCACGACCAGCTGCACACGTACCTGGTCCTGGAGCTGCTG
CGGGGCGGGGAGCTGCTGGAGCACATCCGCAAGAAGCGGCACTTCAGCGAGTCGGAAGCA
AGCCAGATCCTGCGCAGCCTCGTGTCGGCCGTGAGCTTCATGCACGAGGAGGCGGGCGTG
GTGCACCGCGACCTCAAGCCGGAGAACATCCTGTACGCCGACGACACGCCCGGGGCCCCG
GTGAAAATCATCGACTTCGGGTTCGCGCGGTTGCGGCCGCAGAGTCCCGGGGTGCCCATG
CAGACGCCCTGCTTCACGCTGCAGTACGCTGCCCCCGAGCTGCTGGCGCAGCAGGGCTAC
GACGAGTCCTGCGACCTCTGGAGCCTGGGCGTCATTCTGTACATGATGCTGTCGGGGCAG
GTCCCCTTCCAGGGGGCCTCTGGCCAGGGCGGGCAGAGCCAGGCGGCCGAGATCATGTGC
AAAATCCGCGAGGGGCGCTTCTCCCTTGACGGGGAGGCCTGGCAGGGTGTATCCGAGGAA
GCCAAGGAGCTGGTCCGAGGGCTCCTGACCGTGGACCCCGCCAAGCGGCTGAAGCTCGAG
GGACTGCGGGGCAGCTCGTGGCTGCAGGACGGCAGCGCGCGCTCCTCGCCCCCGCTCCGG
ACGCCCGACGTGCTCGAGTCCTCTGGGCCCGCAGTGCGCTCGGGTCTCAACGCCACCTTC
ATGGCATTCAACCGGGGCAAGCGGGAGGGCTTCTTCCTGAAGAGCGTGGAGAATGCACCC
CTGGCCAAGCGGCGGAAGCAGAAGCTGCGGAGCGCCACCGCCTCCCGCCGGGGCTCCCCT
GCACCAGCCAACCCGGGCCGAGCCCCCGTCGCCTCCAAAGGGGCCCCCCGCCGAGCCAAC
GGCCCCCTGCCCCCCTCCTAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome Location11
LocusNone
References
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