NAD(P)H dehydrogenase (quinone)

NameNAD(P)H dehydrogenase (quinone)
Synonyms
  • 1.6.5.2
  • Flavoprotein WrbA
  • NAD(P)H:quinone oxidoreductase
  • NQO
Gene NameNone
OrganismDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Amino acid sequence
>lcl|BSEQ0016973|NAD(P)H dehydrogenase (quinone)
MTAPVKLAIVFYSSTGTGYAMAQEAAEAGRAAGAEVRLLKVRETAPQDVIDGQDAWKANI
EAMKDVPEATPADLEWAEAIVFSSPTRFGGATSQMRAFIDTLGGLWSSGKLANKTFSAMT
SAQNVNGGQETTLQTLYMTAMHWGAVLTPPGYTDEVIFKSGGNPYGASVTANGQPLLEND
RASIRHQVRRQVELTAKLLG
Number of residuesNone
Molecular Weight21297.875
Theoretical pI5.27
GO Classification
Functions
  • FMN binding
  • NAD(P)H dehydrogenase (quinone) activity
Processes
  • negative regulation of transcription, DNA-templated
Components
General FunctionNad(p)h dehydrogenase (quinone) activity
Specific FunctionIt seems to function in response to environmental stress when various electron transfer chains are affected or when the environment is highly oxidizing. It reduces quinones to the hydroquinone state to prevent interaction of the semiquinone with O2 and production of superoxide (By similarity).
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ9RYU4
UniProtKB Entry Name
Cellular LocationNone
Gene sequence
>lcl|BSEQ0016974|NAD(P)H dehydrogenase (quinone)
ATGACCGCTCCTGTCAAGCTCGCCATCGTCTTTTATTCCAGCACCGGCACCGGCTACGCC
ATGGCCCAGGAAGCCGCCGAGGCGGGCCGCGCCGCCGGGGCCGAGGTGCGGCTGCTCAAG
GTGCGCGAAACTGCTCCGCAAGACGTGATTGACGGCCAGGACGCCTGGAAAGCCAACATC
GAGGCGATGAAAGACGTACCAGAGGCGACCCCCGCCGACCTCGAATGGGCCGAAGCCATC
GTGTTCAGCTCGCCCACCCGTTTCGGCGGCGCGACGAGCCAGATGCGGGCGTTCATCGAC
ACCCTCGGCGGCCTGTGGTCAAGCGGCAAACTGGCGAACAAGACCTTCAGCGCAATGACT
TCGGCCCAGAATGTCAACGGCGGCCAGGAAACTACCCTGCAAACGCTGTACATGACGGCG
ATGCACTGGGGCGCGGTTCTGACGCCTCCCGGCTACACCGACGAGGTGATTTTCAAGTCC
GGTGGCAACCCCTACGGCGCGAGCGTAACCGCCAACGGCCAGCCGCTGCTGGAGAATGAC
CGGGCGAGCATCCGCCATCAGGTCAGGCGGCAGGTGGAGTTGACGGCGAAGCTGCTCGGC
TGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome LocationNone
LocusNone
References
  1. White O, Eisen JA, Heidelberg JF, Hickey EK, Peterson JD, Dodson RJ, Haft DH, Gwinn ML, Nelson WC, Richardson DL, Moffat KS, Qin H, Jiang L, Pamphile W, Crosby M, Shen M, Vamathevan JJ, Lam P, McDonald L, Utterback T, Zalewski C, Makarova KS, Aravind L, Daly MJ, Minton KW, Fleischmann RD, Ketchum KA, Nelson KE, Salzberg S, Smith HO, Venter JC, Fraser CM: Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1. Science. 1999 Nov 19;286(5444):1571-7. [10567266 ]
  2. Gorman J, Shapiro L: Crystal structures of the tryptophan repressor binding protein WrbA and complexes with flavin mononucleotide. Protein Sci. 2005 Dec;14(12):3004-12. [16322580 ]

From www.t3db.ca