Isopentenyl-diphosphate delta-isomerase

NameIsopentenyl-diphosphate delta-isomerase
Synonyms
  • 5.3.3.2
  • idi
  • IDI-2
  • IPP isomerase
  • Isopentenyl diphosphate:dimethylallyl diphosphate isomerase
  • Isopentenyl pyrophosphate isomerase
  • Type 2 isopentenyl diphosphate isomerase
  • ypgA
Gene Namefni
OrganismBacillus subtilis (strain 168)
Amino acid sequence
>lcl|BSEQ0005938|Isopentenyl-diphosphate delta-isomerase
MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVDISTKIGELSSSSPIFI
NAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPSERLSYEIVRKENPNGLIF
ANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGDRSFSGALKRIEQICSRVSVP
VIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSKIENLRRQRQISFFNSWGISTAA
SLAEIRSEFPASTMIASGGLQDALDVAKAIALGASCTGMAGHFLKALTDSGEEGLLEEIQ
LILEELKLIMTVLGARTIADLQKAPLVIKGETHHWLTERGVNTSSYSVR
Number of residuesNone
Molecular Weight37220.19
Theoretical pI6.64
GO Classification
Functions
  • FMN binding
  • oxidoreductase activity
  • magnesium ion binding
  • isopentenyl-diphosphate delta-isomerase activity
  • NADPH binding
Processes
  • isoprenoid biosynthetic process
Components
  • cytoplasm
General FunctionOxidoreductase activity
Specific FunctionInvolved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP50740
UniProtKB Entry Name
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0020644|Isopentenyl-diphosphate delta-isomerase (fni)
GTGACTCGAGCAGAACGAAAAAGACAACACATCAATCATGCCTTGTCCATCGGCCAGAAG
CGGGAAACAGGTCTTGATGATATTACGTTTGTTCACGTCAGTCTGCCCGATCTTGCATTA
GAACAAGTAGATATTTCCACAAAAATCGGCGAACTTTCAAGCAGTTCGCCGATTTTTATC
AATGCAATGACTGGCGGCGGCGGAAAACTTACATATGAGATTAATAAATCGCTTGCGCGA
GCGGCTTCTCAGGCTGGAATTCCCCTTGCTGTGGGATCGCAAATGTCAGCATTAAAAGAT
CCATCAGAGCGTCTTTCCTATGAAATTGTTCGAAAGGAAAACCCAAACGGGCTGATTTTT
GCCAACCTGGGAAGCGAGGCAACGGCTGCTCAGGCAAAGGAAGCCGTTGAGATGATTGGA
GCAAACGCACTGCAGATCCACCTCAATGTGATTCAGGAAATTGTGATGCCTGAAGGGGAC
AGAAGCTTTAGCGGCGCATTGAAACGCATTGAACAAATTTGCAGCCGGGTCAGTGTACCG
GTCATTGTGAAAGAAGTCGGCTTCGGTATGAGCAAAGCATCAGCAGGAAAGCTGTATGAA
GCTGGTGCTGCAGCTGTTGACATTGGCGGTTACGGGGGAACAAATTTCTCGAAAATCGAA
AATCTCCGAAGACAGCGGCAAATCTCCTTTTTTAATTCGTGGGGCATTTCGACAGCTGCA
AGTTTGGCGGAAATCCGCTCTGAGTTTCCTGCAAGCACCATGATCGCCTCTGGCGGTCTG
CAAGATGCGCTTGACGTGGCAAAGGCAATTGCGCTGGGGGCCTCTTGCACCGGAATGGCA
GGGCATTTTTTAAAAGCGCTGACTGACAGCGGTGAGGAAGGACTGCTTGAGGAGATTCAG
CTGATCCTTGAGGAATTAAAGTTGATTATGACCGTGCTGGGTGCCAGAACAATTGCCGAT
TTACAAAAGGCGCCCCTTGTGATCAAAGGTGAAACCCATCATTGGCTCACAGAGAGAGGG
GTCAATACATCAAGCTATAGTGTGCGATAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome LocationNone
LocusNone
References
  1. Sorokin A, Azevedo V, Zumstein E, Galleron N, Ehrlich SD, Serror P: Sequence analysis of the Bacillus subtilis chromosome region between the serA and kdg loci cloned in a yeast artificial chromosome. Microbiology. 1996 Aug;142 ( Pt 8):2005-16. [8760912 ]
  2. Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [9384377 ]
  3. Steinbacher S, Kaiser J, Gerhardt S, Eisenreich W, Huber R, Bacher A, Rohdich F: Crystal structure of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Bacillus subtilis. J Mol Biol. 2003 Jun 20;329(5):973-82. [12798687 ]

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