NADH dehydrogenase

NameNADH dehydrogenase
Synonyms
  • 1.6.99.3
  • H(2)O(2)-forming NADH oxidase
  • NADH:oxygen oxidoreductase
Gene Namenox
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Amino acid sequence
>lcl|BSEQ0012129|NADH dehydrogenase
MEATLPVLDAKTAALKRRSIRRYRKDPVPEGLLREILEAALRAPSAWNLQPWRIVVVRDP
ATKRALREAAFGQAHVEEAPVVLVLYADLEDALAHLDEVIHPGVQGERREAQKQAIQRAF
AAMGQEARKAWASGQSYILLGYLLLLLEAYGLGSVPMLGFDPERVRAILGLPSHAAIPAL
VALGYPAEEGYPSHRLPLERVVLWR
Number of residuesNone
Molecular Weight22730.15
Theoretical pI9.31
GO Classification
Functions
  • NADH dehydrogenase activity
Processes
Components
General FunctionNadh dehydrogenase activity
Specific FunctionCan oxidize either NADH or NADPH with a preference for NADH. Can catalyze electron transfer from NADH to various electron acceptors which include, in addition to molecular oxygen, cytochrome c, 2,6 dichlorphenolindophenol, methylene blue, ferricyanide or P-nitroblue tetrazolium.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ60049
UniProtKB Entry Name
Cellular LocationNone
Gene sequence
>lcl|BSEQ0012130|NADH dehydrogenase (nox)
ATGGAGGCGACCCTTCCCGTTTTGGACGCGAAGACGGCGGCCCTAAAGAGGCGTTCCATC
CGGCGTTACCGGAAGGACCCCGTACCCGAGGGGCTTCTCCGGGAAATCCTCGAGGCCGCC
CTCCGGGCGCCCTCGGCCTGGAACCTCCAGCCCTGGCGGATCGTGGTGGTGCGGGACCCC
GCCACCAAACGGGCCCTGAGGGAGGCGGCCTTCGGCCAGGCCCACGTGGAGGAGGCCCCC
GTGGTCCTGGTCCTCTACGCCGACCTCGAGGACGCTCTCGCCCACCTGGACGAGGTCATC
CACCCCGGGGTCCAGGGGGAAAGGCGTGAGGCGCAGAAGCAGGCCATCCAACGGGCCTTC
GCCGCCATGGGGCAAGAGGCGCGAAAGGCCTGGGCCTCCGGGCAGAGCTACATCCTCTTG
GGCTACCTCCTTCTCCTCCTGGAGGCTTATGGCCTCGGAAGCGTCCCCATGCTGGGGTTT
GACCCCGAGAGGGTGAGGGCGATCCTGGGGCTTCCTTCCCACGCCGCCATCCCCGCCCTG
GTGGCCTTGGGCTACCCGGCGGAGGAGGGCTACCCCTCCCACCGCCTGCCCCTGGAGCGG
GTGGTCCTCTGGCGCTAG
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome LocationNone
LocusNone
References
  1. Park HJ, Kreutzer R, Reiser CO, Sprinzl M: Molecular cloning and nucleotide sequence of the gene encoding a H2O2-forming NADH oxidase from the extreme thermophilic Thermus thermophilus HB8 and its expression in Escherichia coli. Eur J Biochem. 1992 May 1;205(3):875-9. [1577004 ]
  2. Park HJ, Kreutzer R, Reiser CO, Sprinzl M: Molecular cloning and nucleotide sequence of the gene encoding a H2O2-forming NADH oxidase from the extreme thermophilic Thermus thermophilus HB8 and its expression in Escherichia coli. Eur J Biochem. 1993 Feb 1;211(3):909. [8436145 ]
  3. Park HJ, Reiser CO, Kondruweit S, Erdmann H, Schmid RD, Sprinzl M: Purification and characterization of a NADH oxidase from the thermophile Thermus thermophilus HB8. Eur J Biochem. 1992 May 1;205(3):881-5. [1577005 ]
  4. Hecht HJ, Erdmann H, Park HJ, Sprinzl M, Schmid RD: Crystal structure of NADH oxidase from Thermus thermophilus. Nat Struct Biol. 1995 Dec;2(12):1109-14. [8846223 ]

From www.t3db.ca