Epidermin decarboxylase

NameEpidermin decarboxylase
Synonyms
  • 4.1.1.-
  • Epidermin-modifying enzyme EpiD
Gene NameepiD
OrganismStaphylococcus epidermidis
Amino acid sequence
>lcl|BSEQ0012112|Epidermin decarboxylase
MYGKLLICATASINVININHYIVELKQHFDEVNILFSPSSKNFINTDVLKLFCDNLYDEI
KDPLLNHINIVENHEYILVLPASANTINKIANGICDNLLTTVCLTGYQKLFIFPNMNIRM
WGNPFLQKNIDLLKNNDVKVYSPDMNKSFEISSGRYKNNITMPNIENVLNFVLNNEKRPL
D
Number of residuesNone
Molecular Weight20824.89
Theoretical pI6.5
GO Classification
Functions
  • lyase activity
Processes
Components
General FunctionLyase activity
Specific FunctionCatalyzes the removal of two reducing equivalents (oxidative decarboxylation) from the cysteine residue of the C-terminal meso-lanthionine of epidermin to form a --C==C-- double bond.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP30197
UniProtKB Entry Name
Cellular LocationNone
Gene sequence
>lcl|BSEQ0005897|546 bp
ATGTATGGAAAATTATTGATATGCGCTACAGCATCGATAAATGTAATTAATATTAATCAC
TACATAGTTGAGTTAAAGCAACATTTTGATGAAGTTAATATATTATTTAGTCCTAGTAGT
AAAAATTTTATAAATACTGATGTTCTCAAGTTATTTTGTGATAACTTGTACGATGAAATT
AAAGATCCTCTTTTAAATCATATCAATATTGTAGAAAATCATGAATATATTTTAGTATTA
CCTGCATCAGCAAATACTATTAATAAAATAGCTAATGGTATATGTGATAATCTTTTAACT
ACTGTATGTTTAACCGGATATCAAAAATTATTTATATTTCCAAATATGAACATAAGAATG
TGGGGAAATCCATTTTTACAAAAAAATATTGATTTACTTAAAAATAATGATGTGAAAGTG
TATTCCCCTGATATGAATAAATCATTCGAAATATCTAGTGGCCGTTACAAAAACAATATC
ACAATGCCTAATATTGAAAATGTACTAAATTTTGTATTAAATAACGAAAAAAGACCTTTG
GATTAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome LocationNone
LocusNone
References
  1. Schnell N, Engelke G, Augustin J, Rosenstein R, Ungermann V, Gotz F, Entian KD: Analysis of genes involved in the biosynthesis of lantibiotic epidermin. Eur J Biochem. 1992 Feb 15;204(1):57-68. [1740156 ]
  2. Kupke T, Stevanovic S, Sahl HG, Gotz F: Purification and characterization of EpiD, a flavoprotein involved in the biosynthesis of the lantibiotic epidermin. J Bacteriol. 1992 Aug;174(16):5354-61. [1644762 ]
  3. Kupke T, Uebele M, Schmid D, Jung G, Blaesse M, Steinbacher S: Molecular characterization of lantibiotic-synthesizing enzyme EpiD reveals a function for bacterial Dfp proteins in coenzyme A biosynthesis. J Biol Chem. 2000 Oct 13;275(41):31838-46. [10922366 ]
  4. Blaesse M, Kupke T, Huber R, Steinbacher S: Crystal structure of the peptidyl-cysteine decarboxylase EpiD complexed with a pentapeptide substrate. EMBO J. 2000 Dec 1;19(23):6299-310. [11101502 ]

From www.t3db.ca