Chorismate synthase

Name	Chorismate synthase
Synonyms	4.2.3.5 5-enolpyruvylshikimate-3-phosphate phospholyase CS
Gene Name	aroC
Organism	Helicobacter pylori (strain ATCC 700392 / 26695)
Amino acid sequence	>lcl\|BSEQ0012113\|Chorismate synthase MNTLGRFLRLTTFGESHGDVIGGVLDGMPSGIKIDYALLENEMKRRQGGRNVFITPRKED DKVEITSGVFEDFSTGTPIGFLIHNQRARSKDYDNIKNLFRPSHADFTYFHKYGIRDFRG GGRSSARESAIRVAAGAFAKMLLREIGIVCESGIIEIGGIKAKNYDFNHALKSEIFALDE EQEEAQKTAIQNAIKNHDSIGGVALIRARSIKTNQKLPIGLGQGLYAKLDAKIAEAMMGL NGVKAVEIGKGVESSLLKGSEYNDLMDQKGFLSNRSGGVLGGMSNGEEIIVRVHFKPTPS IFQPQRTIDINGNECECLLKGRHDPCIAIRGSVVCESLLALVLADMVLLNLTSKIEYLKT IYNEN
Number of residues	None
Molecular Weight	40099.6
Theoretical pI	8.21
GO Classification	Functions FMN binding chorismate synthase activity Processes aromatic amino acid family biosynthetic process chorismate biosynthetic process Components
General Function	Fmn binding
Specific Function	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	P56122
UniProtKB Entry Name
Cellular Location	None
Gene sequence	>lcl\|BSEQ0012114\|Chorismate synthase (aroC) ATGAACACTTTGGGGCGTTTTTTAAGGCTCACGACTTTTGGGGAATCGCATGGGGATGTG ATAGGGGGGGTATTAGACGGCATGCCTAGCGGGATTAAAATAGACTATGCGCTATTAGAA AATGAAATGAAGCGCCGCCAAGGGGGGAGGAACGTTTTCATTACGCCACGAAAAGAAGAC GATAAAGTGGAAATAACAAGCGGGGTTTTTGAAGATTTTAGCACAGGGACTCCTATAGGG TTTTTAATCCACAACCAAAGGGCTAGGAGCAAGGATTACGATAACATTAAAAACCTTTTT AGGCCTAGCCATGCGGATTTCACTTATTTTCATAAATACGGCATTAGGGATTTTAGGGGT GGGGGGAGGAGTTCGGCCAGAGAGAGTGCTATAAGAGTGGCTGCTGGGGCGTTTGCTAAA ATGCTTTTAAGAGAAATCGGTATTGTTTGTGAAAGCGGGATTATAGAAATTGGGGGTATT AAAGCCAAAAATTATGATTTTAATCACGCCTTAAAAAGCGAGATTTTTGCCCTAGATGAA GAACAAGAAGAAGCGCAAAAAACAGCCATTCAAAACGCTATCAAAAACCACGATAGCATA GGGGGTGTGGCTTTGATTAGAGCGAGGAGCATAAAAACCAATCAAAAGCTCCCCATTGGC TTAGGTCAAGGGCTATACGCTAAATTAGACGCTAAAATCGCTGAAGCGATGATGGGGCTT AATGGGGTGAAAGCGGTTGAAATAGGCAAGGGGGTAGAAAGCTCTTTATTAAAAGGCTCA GAGTATAATGATTTAATGGATCAAAAGGGGTTTTTGAGCAATCGTAGCGGAGGGGTTTTA GGGGGCATGAGCAATGGGGAAGAAATCATTGTTAGAGTGCATTTCAAACCCACGCCAAGC ATTTTCCAACCTCAACGAACCATAGACATTAATGGCAATGAGTGCGAATGCTTGTTAAAG GGCAGGCATGATCCTTGCATTGCGATTAGAGGGAGCGTGGTGTGCGAGAGTTTGTTAGCG TTGGTGTTGGCTGATATGGTATTACTCAATTTGACTTCAAAAATAGAGTATTTAAAAACG ATTTATAATGAGAATTAA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Tomb JF, White O, Kerlavage AR, Clayton RA, Sutton GG, Fleischmann RD, Ketchum KA, Klenk HP, Gill S, Dougherty BA, Nelson K, Quackenbush J, Zhou L, Kirkness EF, Peterson S, Loftus B, Richardson D, Dodson R, Khalak HG, Glodek A, McKenney K, Fitzegerald LM, Lee N, Adams MD, Hickey EK, Berg DE, Gocayne JD, Utterback TR, Peterson JD, Kelley JM, Cotton MD, Weidman JM, Fujii C, Bowman C, Watthey L, Wallin E, Hayes WS, Borodovsky M, Karp PD, Smith HO, Fraser CM, Venter JC: The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature. 1997 Aug 7;388(6642):539-47. [9252185 ] Ahn HJ, Yoon HJ, Lee B 2nd, Suh SW: Crystal structure of chorismate synthase: a novel FMN-binding protein fold and functional insights. J Mol Biol. 2004 Feb 27;336(4):903-15. [15095868 ]

From www.t3db.ca