Probable aromatic acid decarboxylase

NameProbable aromatic acid decarboxylase
Synonyms
  • 2.5.1.-
  • 4-hydroxybenzoate decarboxylase subunit B
  • pad1
  • Phenolic acid decarboxylase subunit B
Gene NameecdB
OrganismEscherichia coli O157:H7
Amino acid sequence
>lcl|BSEQ0016964|Probable UbiX-like flavin prenyltransferase
MKLIVGMTGATGAPLGVALLQALREMPNVETHLVMSKWAKTTIELETPYSARDVAALADF
SHNPADQAATISSGSFRTDGMIVIPCSMKTLAGIRAGYADGLVGRAADVVLKEGRKLVLV
PREMPLSTIHLENMLALSRMGVAMVPPMPAFYNHPETVDDIVHHVVARVLDQFGLEHPYA
RRWQGLPQARNFSQENE
Number of residuesNone
Molecular Weight21469.72
Theoretical pI6.89
GO Classification
Functions
  • prenyltransferase activity
Processes
Components
General FunctionPrenyltransferase activity
Specific FunctionFlavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for phenolic acid decarboxylase C (By similarity). Involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions (PubMed:15979273).
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP69772
UniProtKB Entry Name
Cellular LocationNone
Gene sequence
>lcl|BSEQ0016965|Probable UbiX-like flavin prenyltransferase (ecdB)
ATGAAACTGATCGTCGGGATGACAGGGGCTACCGGTGCGCYTCTTGGTGTGGCATTACTG
CAAGCGCTGCGGGAGATGCCGAATGTCGAGACTCATCTGGTGATGTCGAAGTGGGCGAAA
ACCACCATTGAACTGGAAACGCCTTACAGCGCCCGCGATGTTGCTGCCCTCGCTGACTTC
AGCCATAACCCGGCGGATCAGGCGGCGACCATCTCCTCAGGTTCCTTTCGTACAGACGGC
ATGATCGTTATTCCGTGCAGTATGAAAACGCTCGCCGGTATCCGCGCTGGTTACGCTGAT
GGCCTGGTAGGGCGCGCGGCGGACGTCGTGCTTAAAGAAGGCCGCAAACTGGTGCTGGTG
CCGCGTGAAATGCCGCTTAGCACCATCCATCTCGAAAATATGCTCGCACTTTCACGCATG
GGCGTGGCGATGGTGCCGCCGATGCCTGCCTTTTATAACCATCCCGAAACGGTAGATGAC
ATTGTCCACCACGTGGTAGCCCGCGTGCTGGATCAATTTGGCCTTGAACATCCCTACGCC
AGGCGCTGGCAAGGATTGCCGCAGGCCCGGAATTTTTCTCAGGAGAATGAATAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome LocationNone
LocusNone
References
  1. Perna NT, Plunkett G 3rd, Burland V, Mau B, Glasner JD, Rose DJ, Mayhew GF, Evans PS, Gregor J, Kirkpatrick HA, Posfai G, Hackett J, Klink S, Boutin A, Shao Y, Miller L, Grotbeck EJ, Davis NW, Lim A, Dimalanta ET, Potamousis KD, Apodaca J, Anantharaman TS, Lin J, Yen G, Schwartz DC, Welch RA, Blattner FR: Genome sequence of enterohaemorrhagic Escherichia coli O157:H7. Nature. 2001 Jan 25;409(6819):529-33. [11206551 ]
  2. Hayashi T, Makino K, Ohnishi M, Kurokawa K, Ishii K, Yokoyama K, Han CG, Ohtsubo E, Nakayama K, Murata T, Tanaka M, Tobe T, Iida T, Takami H, Honda T, Sasakawa C, Ogasawara N, Yasunaga T, Kuhara S, Shiba T, Hattori M, Shinagawa H: Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12. DNA Res. 2001 Feb 28;8(1):11-22. [11258796 ]
  3. Lupa B, Lyon D, Gibbs MD, Reeves RA, Wiegel J: Distribution of genes encoding the microbial non-oxidative reversible hydroxyarylic acid decarboxylases/phenol carboxylases. Genomics. 2005 Sep;86(3):342-51. [15979273 ]
  4. Rangarajan ES, Li Y, Iannuzzi P, Tocilj A, Hung LW, Matte A, Cygler M: Crystal structure of a dodecameric FMN-dependent UbiX-like decarboxylase (Pad1) from Escherichia coli O157: H7. Protein Sci. 2004 Nov;13(11):3006-16. Epub 2004 Sep 30. [15459342 ]

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