Oxygen-insensitive NAD(P)H nitroreductase

Name	Oxygen-insensitive NAD(P)H nitroreductase
Synonyms	1.-.-.- nfnB nfsI NR
Gene Name	nfsB
Organism	Enterobacter cloacae
Amino acid sequence	>lcl\|BSEQ0016966\|Oxygen-insensitive NAD(P)H nitroreductase MDIISVALKRHSTKAFDASKKLTAEEAEKIKTLLQYSPSSTNSQPWHFIVASTEEGKARV AKSAAGTYVFNERKMLDASHVVVFCAKTAMDDAWLERVVDQEEADGRFNTPEAKAANHKG RTYFADMHRVDLKDDDQWMAKQVYLNVGNFLLGVGAMGLDAVPIEGFDAAILDEEFGLKE KGFTSLVVVPVGHHSVEDFNATLPKSRLPLSTIVTEC
Number of residues	None
Molecular Weight	23949.98
Theoretical pI	5.61
GO Classification	Functions oxidoreductase activity Processes Components
General Function	Oxidoreductase activity
Specific Function	Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred.
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	Q01234
UniProtKB Entry Name
Cellular Location	None
Gene sequence	>lcl\|BSEQ0005921\|654 bp ATGGATATCATTTCTGTCGCCCTGAAACGCCACTCTACCAAGGCGTTCGACGCAAGCAAA AAACTGACCGCGGAAGAAGCGGAAAAAATCAAAACCCTGCTGCAGTACAGCCCGTCCAGC ACCAACTCCCAGCCGTGGCACTTCATTGTAGCCAGCACCGAGGAAGGAAAAGCGCGCGTG GCGAAGTCCGCTGCGGGCACCTATGTGTTCAACGAACGCAAAATGCTGGATGCTTCCCAC GTGGTGGTGTTCTGCGCGAAAACCGCGATGGATGACGCCTGGCTGGAGCGCGTCGTGGAT CAGGAAGAGGCCGATGGCCGTTTCAACACGCCGGAAGCCAAAGCCGCAAACCATAAGGGC CGCACCTACTTCGCCGACATGCACCGCGTGGATCTGAAAGATGACGACCAGTGGATGGCG AAGCAGGTTTACCTGAACGTCGGCAACTTCCTGCTGGGCGTGGGCGCGATGGGTCTGGAC GCGGTACCAATTGAAGGTTTCGACGCCGCTATTCTCGACGAAGAGTTTGGCCTGAAAGAG AAAGGCTTCACCAGCCTGGTGGTGGTACCGGTTGGGCACCACAGCGTGGAAGATTTCAAC GCCACGCTGCCGAAATCTCGCCTGCCGCTGAGCACGATTGTGACCGAGTGCTGA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Bryant C, Hubbard L, McElroy WD: Cloning, nucleotide sequence, and expression of the nitroreductase gene from Enterobacter cloacae. J Biol Chem. 1991 Mar 5;266(7):4126-30. [1999406 ] Bryant C, DeLuca M: Purification and characterization of an oxygen-insensitive NAD(P)H nitroreductase from Enterobacter cloacae. J Biol Chem. 1991 Mar 5;266(7):4119-25. [1999405 ] Haynes CA, Koder RL, Miller AF, Rodgers DW: Structures of nitroreductase in three states: effects of inhibitor binding and reduction. J Biol Chem. 2002 Mar 29;277(13):11513-20. Epub 2002 Jan 22. [11805110 ]

From www.t3db.ca