Isopentenyl-diphosphate delta-isomerase

NameIsopentenyl-diphosphate delta-isomerase
Synonyms
  • 5.3.3.2
  • IDI-2
  • IPP isomerase
  • Isopentenyl diphosphate:dimethylallyl diphosphate isomerase
  • Isopentenyl pyrophosphate isomerase
  • Type 2 isopentenyl diphosphate isomerase
Gene Namefni
OrganismThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Amino acid sequence
>lcl|BSEQ0016967|Isopentenyl-diphosphate delta-isomerase
MNIRERKRKHLEACLEGEVAYQKTTTGLEGFRLRYQALAGLALGEVDLTTPFLGKTLKAP
FLIGAMTGGEENGERINLALAEAAEALGVGMMLGSGRILLERPEALRSFRVRKVAPKALL
IANLGLAQLRRYGRDDLLRLVEALEADALAFHVNPLQEAVQRGDTDFRGLVERLAELLPL
PFPVMVKEVGHGLSREAALALRDLPLAAVDVAGAGGTSWARVEEWVRFGEVRHPELCEIG
IPTARAILEVREVLPHLPLVASGGVYTGTDGAKALALGADLLAVARPLLRPALEGAERVA
AWIGDYLEELRTALFAIGAKNPKEARGRVERV
Number of residuesNone
Molecular Weight35900.305
Theoretical pI7.07
GO Classification
Functions
  • FMN binding
  • oxidoreductase activity
  • magnesium ion binding
  • isopentenyl-diphosphate delta-isomerase activity
  • NADPH binding
Processes
  • isoprenoid biosynthetic process
Components
  • cytoplasm
General FunctionOxidoreductase activity
Specific FunctionInvolved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ746I8
UniProtKB Entry Name
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0016968|Isopentenyl-diphosphate delta-isomerase (fni)
GTGAACATCCGGGAGAGGAAGCGGAAGCACCTCGAGGCCTGCCTGGAAGGCGAGGTGGCC
TACCAGAAGACCACCACGGGGCTGGAAGGCTTCCGCCTCCGCTACCAGGCCCTGGCGGGC
CTCGCCCTAGGCGAGGTGGACCTCACCACCCCCTTCCTGGGGAAGACCCTGAAGGCCCCC
TTCCTCATCGGGGCCATGACCGGGGGGGAGGAAAACGGGGAGAGGATCAACCTGGCCCTG
GCGGAGGCCGCGGAGGCCTTAGGGGTGGGGATGATGCTGGGCTCGGGCAGGATCCTTCTG
GAGCGCCCCGAGGCCCTAAGGAGCTTCCGGGTGCGGAAGGTGGCCCCAAAGGCGCTCCTC
ATCGCCAACCTGGGCCTCGCCCAGCTCAGGCGCTACGGGCGGGACGACCTCCTCCGGCTC
GTGGAGGCCCTGGAGGCGGACGCCCTCGCCTTCCACGTGAACCCCCTGCAGGAGGCGGTG
CAGCGGGGGGACACGGACTTCCGGGGCCTGGTGGAGAGGCTCGCCGAACTCCTCCCCCTC
CCCTTCCCCGTGATGGTGAAGGAGGTGGGGCACGGCCTCTCCCGGGAGGCGGCCTTGGCC
CTACGGGACCTCCCCTTGGCGGCGGTGGACGTGGCCGGGGCCGGGGGGACGAGCTGGGCC
CGGGTGGAGGAGTGGGTGCGCTTCGGGGAGGTGCGCCACCCGGAGCTCTGCGAGATCGGG
ATCCCCACGGCGAGGGCCATCCTCGAGGTGCGGGAGGTCCTGCCCCACCTCCCCCTCGTG
GCCTCCGGCGGGGTCTACACGGGGACGGACGGGGCCAAGGCCCTGGCCCTGGGGGCGGAC
CTCTTGGCGGTGGCGCGCCCCCTCCTCAGGCCCGCCCTGGAGGGGGCGGAAAGGGTGGCG
GCCTGGATCGGGGACTACCTGGAAGAACTTAGGACCGCCCTCTTCGCCATCGGGGCCAAG
AACCCGAAGGAAGCCCGGGGGCGGGTGGAGCGGGTGTAG
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome LocationNone
LocusNone
References
  1. Henne A, Bruggemann H, Raasch C, Wiezer A, Hartsch T, Liesegang H, Johann A, Lienard T, Gohl O, Martinez-Arias R, Jacobi C, Starkuviene V, Schlenczeck S, Dencker S, Huber R, Klenk HP, Kramer W, Merkl R, Gottschalk G, Fritz HJ: The genome sequence of the extreme thermophile Thermus thermophilus. Nat Biotechnol. 2004 May;22(5):547-53. Epub 2004 Apr 4. [15064768 ]
  2. Rothman SC, Helm TR, Poulter CD: Kinetic and spectroscopic characterization of type II isopentenyl diphosphate isomerase from Thermus thermophilus: evidence for formation of substrate-induced flavin species. Biochemistry. 2007 May 8;46(18):5437-45. Epub 2007 Apr 12. [17428035 ]

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