Octanoyltransferase

Name	Octanoyltransferase
Synonyms	2.3.1.181 Lipoate-protein ligase B Lipoyl/octanoyl transferase Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase
Gene Name	lipB
Organism	Mycobacterium tuberculosis
Amino acid sequence	>lcl\|BSEQ0051229\|Octanoyltransferase MTGSIRSKLSAIDVRQLGTVDYRTAWQLQRELADARVAGGADTLLLLEHPAVYTAGRRTE THERPIDGTPVVDTDRGGKITWHGPGQLVGYPIIGLAEPLDVVNYVRRLEESLIQVCADL GLHAGRVDGRSGVWLPGRPARKVAAIGVRVSRATTLHGFALNCDCDLAAFTAIVPCGISD AAVTSLSAELGRTVTVDEVRATVAAAVCAALDGVLPVGDRVPSHAVPSPL
Number of residues	None
Molecular Weight	24210.415
Theoretical pI	None
GO Classification	Functions lipoyl(octanoyl) transferase activity octanoyltransferase activity Processes growth protein lipoylation lipoate biosynthetic process Components cytoplasm plasma membrane
General Function	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
Specific Function	Lipoyl(octanoyl) transferase activity
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	P9WK83
UniProtKB Entry Name
Cellular Location	Cytoplasm
Gene sequence	>lcl\|BSEQ0051230\|Octanoyltransferase (lipB) GTGACGGGTTCTATCCGGTCGAAGCTGTCCGCGATCGACGTCCGCCAGCTGGGGACCGTC GACTACCGGACCGCGTGGCAGCTACAGCGAGAGCTAGCCGACGCCCGGGTCGCCGGCGGC GCCGACACGCTGCTGCTGTTGGAACACCCCGCGGTCTACACCGCCGGACGGCGTACCGAG ACACACGAGCGACCCATTGACGGCACTCCGGTCGTCGACACCGACCGCGGCGGCAAGATC ACCTGGCACGGTCCGGGGCAATTGGTCGGCTACCCGATCATCGGGCTGGCCGAACCCCTC GACGTGGTCAATTACGTTCGGCGCCTTGAAGAATCGCTGATCCAAGTCTGCGCCGATCTG GGCCTGCACGCCGGCCGCGTCGACGGCCGGTCCGGGGTCTGGCTGCCCGGCAGGCCGGCG CGCAAGGTCGCGGCCATCGGTGTCCGGGTGTCGCGGGCGACGACACTGCACGGGTTTGCG CTCAACTGCGATTGTGATTTGGCTGCCTTCACCGCCATCGTGCCATGCGGAATCAGTGAC GCCGCAGTGACATCGCTGTCCGCCGAACTCGGCCGTACGGTCACCGTCGACGAGGTCCGC GCGACGGTCGCCGCCGCTGTCTGCGCCGCTCTGGACGGCGTCCTACCGGTCGGTGACCGC GTGCCCTCACACGCCGTACCATCGCCGTTATGA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [9634230 ] Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [21969609 ] Ma Q, Zhao X, Nasser Eddine A, Geerlof A, Li X, Cronan JE, Kaufmann SH, Wilmanns M: The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase. Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8662-7. Epub 2006 May 30. [16735476 ]

From www.t3db.ca