Elongation factor Tu GTP-binding domain-containing protein 1

NameElongation factor Tu GTP-binding domain-containing protein 1
Synonyms
  • EFL1
  • Elongation factor-like 1
  • FAM42A
  • Protein FAM42A
Gene NameEFTUD1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0007744|Elongation factor Tu GTP-binding domain-containing protein 1
MVLNSLDKMIQLQKNTANIRNICVLAHVDHGKTTLADCLISSNGIISSRLAGKLRYMDSR
EDEQIRGITMKSSAISLHYATGNEEYLINLIDSPGHVDFSSEVSTAVRICDGCIIVVDAV
EGVCPQTQAVLRQAWLENIRPVLVINKIDRLIVELKFTPQEAYSHLKNILEQINALTGTL
FTSKVLEERAERETESQVNPNSEQGEQVYDWSTGLEDTDDSHLYFSPEQGNVVFTSAIDG
WGFGIEHFARIYSQKIGIKKEVLMKTLWGDYYINMKAKKIMKGDQAKGKKPLFVQLILEN
IWSLYDAVLKKDKDKIDKIVTSLGLKIGAREARHSDPKVQINAICSQWLPISHAVLAMVC
QKLPSPLDITAERVERLMCTGSQTFDSFPPETQALKAAFMKCGSEDTAPVIIFVSKMFAV
DAKALPQNKPRPLTQEEIAQRRERARQRHAEKLAAAQGQAPLEPTQDGSAIETCPKGEEP
RGDEQQVESMTPKPVLQEENNQESFIAFARVFSGVARRGKKIFVLGPKYSPLEFLRRVPL
GFSAPPDGLPQVPHMAYCALENLYLLMGRELEYLEEVPPGNVLGIGGLQDFVLKSATLCS
LPSCPPFIPLNFEATPIVRVAVEPKHPSEMPQLVKGMKLLNQADPCVQILIQETGEHVLV
TAGEVHLQRCLDDLKERFAKIHISVSEPIIPFRETITKPPKVDMVNEEIGKQQKVAVIHQ
MKEDQSKIPEGIQVDSDGLITITTPNKLATLSVRAMPLPEEVTQILEENSDLIRSMEQLT
SSLNEGENTHMIHQKTQEKIWEFKGKLEQHLTGRRWRNIVDQIWSFGPRKCGPNILVNKS
EDFQNSVWTGPADKASKEASRYRDLGNSIVSGFQLATLSGPMCEEPLMGVCFVLEKWDLS
KFEEQGASDLAKEGQEENETCSGGNENQELQDGCSEAFEKRTSQKGESPLTDCYGPFSGQ
LIATMKEACRYALQVKPQRLMAAMYTCDIMATGDVLGRVYAVLSKREGRVLQEEMKEGTD
MFIIKAVLPVAESFGFADEIRKRTSGLASPQLVFSHWEIIPSDPFWVPTTEEEYLHFGEK
ADSENQARKYMNAVRKRKGLYVEEKIVEHAEKQRTLSKNK
Number of residuesNone
Molecular Weight125428.745
Theoretical pI5.72
GO Classification
Functions
  • GTP binding
  • GTPase activity
  • ribosome binding
Processes
  • translation
  • mature ribosome assembly
Components
  • intracellular
General FunctionRibosome binding
Specific FunctionInvolved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ7Z2Z2
UniProtKB Entry Name
Cellular LocationNone
Gene sequence
>lcl|BSEQ0012822|Elongation factor Tu GTP-binding domain-containing protein 1 (EFTUD1)
ATGGTGCTCAACAGTTTGGATAAGATGATTCAACTCCAGAAAAACACTGCCAACATCAGG
AATATTTGTGTTTTGGCTCATGTTGACCATGGTAATGAGGAGTACCTGATCAATCTGATA
GACTCTCCAGGACACGTGGACTTTTCCTCAGAAGTATCAACCGCTGTTCGCATTTGTGAT
GGATGCATCATTGTGGTAGATGCTGTGGAAGGAGTCTGTCCACAGACACAGGCAGTTCTG
CGACAAGCTTGGCTTGAAAACATCCGTCCGGTTTTAGTGATTAATAAGATTGATCGCTTG
ATAGTGGAACTGAAATTCACCCCACAAGAGGCCTATTCTCACCTCAAGAATATTTTAGAA
CAGATTAATGCGCTCACAGGGACTCTTTTTACTTCTAAAGTCCTAGAAGAAAGAGCAGAG
AGGGAGACTGAATCCCAAGTGAATCCAAATTCTGAACAAGGAGAGCAAGTATATGACTGG
AGCACTGGCTTGGAGGACACAGATGATTCTCACCTTTACTTCTCTCCAGAACAGGGAAAT
GTGGTGTTTACCAGTGCAATAGATGGGTGGGGCTTTGGAATTGAGCACTTCGCCAGAATC
TACAGTCAAAAAATTGGCATCAAAAAGGAAGTTCTTATGAAAACCTTGTGGGGAGATTAC
TATATAAATATGAAGGCTAAAAAGATCATGAAGGGTGATCAGGCCAAAGGAAAGAAACCT
TTATTTGTACAGTTGATCCTGGAAAATATATGGAGTTTGTATGATGCTGTTTTGAAAAAG
GACAAAGACAAAATTGATAAAATAGTGACTTCTTTAGGATTAAAAATTGGAGCCCGGGAG
GCACGACATTCAGACCCTAAAGTTCAGATCAACGCCATTTGCAGTCAGTGGCTACCCATA
TCCCATGCTGTTCTTGCTATGGTGTGTCAGAAACTTCCTAGTCCCCTTGATATTACAGCT
GAGAGAGTGGAGAGACTGATGTGCACAGGATCACAAACTTTTGACTCTTTTCCACCAGAA
ACTCAAGCACTGAAAGCAGCTTTTATGAAATGTGGAAGTGAGGACACTGCTCCAGTTATT
ATATTTGTTTCCAAAATGTTTGCAGTTGATGCTAAGGCCTTGCCTCAGAATAAGCCAAGG
CCTCTCACTCAAGAAGAAATTGCTCAGAGACGTGAGCGTGCAAGACAAAGGCATGCAGAG
AAGCTTGCAGCAGCACAGGGACAGGCACCCTTGGAGCCCACCCAAGATGGGAGTGCCATT
GAAACATGTCCAAAAGGAGAGGAGCCAAGAGGTGACGAGCAACAGGTGGAAAGTATGACC
CCTAAACCTGTGCTCCAGGAAGAAAACAACCAAGAGTCTTTTATTGCATTTGCTCGGGTG
TTCAGTGGTGTGGCTCGAAGAGGAAAGAAAATTTTTGTCTTGGGGCCCAAATACAGTCCT
CTTGAGTTTTTACGAAGGGTACCATTAGGCTTCTCAGCTCCACCAGATGGCCTCCCCCAA
GTCCCCCACATGGCATACTGTGCTCTGGAAAACCTGTATCTTCTGATGGGAAGGGAACTG
GAATATCTAGAGGAGGTACCTCCAGGAAATGTGCTAGGAATAGGAGGCCTTCAAGATTTT
GTGCTGAAATCTGCAACACTGTGTAGCCTGCCATCCTGCCCACCATTTATACCACTCAAC
TTCGAAGCCACTCCTATTGTGAGAGTTGCTGTTGAACCAAAACATCCAAGTGAAATGCCT
CAGCTCGTAAAAGGAATGAAACTGTTAAACCAGGCTGATCCCTGTGTCCAGATTTTAATT
CAGGAAACGGGAGAGCACGTTTTAGTCACAGCAGGAGAAGTCCACCTTCAGCGATGCCTG
GATGACTTAAAAGAAAGGTTTGCAAAGATTCATATCAGTGTATCTGAACCTATTATTCCA
TTCAGAGAAACAATCACAAAACCCCCAAAAGTTGACATGGTCAATGAAGAAATAGGCAAA
CAGCAAAAAGTTGCAGTCATACACCAAATGAAAGAAGATCAAAGCAAAATCCCTGAAGGA
ATCCAAGTTGACTCTGACGGGCTAATCACCATAACAACTCCCAATAAACTTGCCACGCTC
AGTGTTCGAGCCATGCCCCTTCCAGAAGAAGTCACCCAGATTCTGGAAGAAAATAGTGAT
TTGATTCGTTCTATGGAGCAGTTGACATCCTCTTTGAATGAGGGTGAAAATACTCACATG
ATTCATCAGAAGACCCAAGAGAAAATTTGGGAATTCAAAGGAAAACTGGAGCAACACCTA
ACAGGGAGAAGATGGAGGAACATTGTTGACCAAATCTGGTCATTTGGCCCAAGAAAATGT
GGGCCCAACATACTAGTCAATAAAAGTGAAGATTTTCAGAACTCAGTATGGACAGGTCCA
GCTGACAAAGCTTCAAAAGAAGCCAGTAGATACCGAGATTTGGGCAATAGCATTGTGAGT
GGCTTCCAACTAGCAACCCTCTCTGGCCCCATGTGTGAGGAGCCTCTCATGGGTGTCTGT
TTTGTTCTGGAAAAATGGGACCTAAGTAAATTTGAGGAACAAGGAGCAAGTGATCTGGCA
AAAGAGGGACAGGAGGAAAATGAAACCTGTTCTGGTGGAAATGAAAACCAAGAGCTACAA
GATGGCTGCTCTGAGGCCTTTGAGAAGAGGACATCACAGAAAGGAGAATCTCCACTCACT
GACTGCTATGGACCTTTCTCAGGACAGCTAATTGCCACCATGAAAGAAGCATGTCGCTAT
GCACTGCAAGTGAAACCTCAGCGCCTGATGGCAGCTATGTACACATGTGACATCATGGCC
ACTGGTGATGTTCTCGGTCGAGTCTATGCTGTCTTGTCAAAGAGAGAAGGTCGGGTACTT
CAAGAAGAAATGAAAGAAGGGACAGACATGTTCATCATCAAGGCTGTGCTGCCTGTTGCT
GAAAGCTTTGGTTTTGCTGATGAAATCAGGAAGAGGACAAGTGGCCTGGCCAGCCCACAA
CTAGTATTCAGCCATTGGGAGATCATTCCCAGTGACCCCTTCTGGGTGCCAACTACTGAG
GAGGAATACTTGCACTTTGGGGAGAAGGCTGACTCTGAGAACCAAGCCCGGAAGTACATG
AACGCAGTACGAAAGCGGAAGGGGCTTTATGTGGAAGAAAAGATTGTGGAGCATGCAGAA
AAGCAGAGGACACTCAGCAAAAATAAGTAG
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome Location15
Locus15q25.2
References
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From www.t3db.ca