HTH-type transcriptional regulator MalT

Name	HTH-type transcriptional regulator MalT
Synonyms	ATP-dependent transcriptional activator MalT malA
Gene Name	malT
Organism	Escherichia coli (strain K12)
Amino acid sequence	>lcl\|BSEQ0011182\|HTH-type transcriptional regulator MalT MLIPSKLSRPVRLDHTVVRERLLAKLSGANNFRLALITSPAGYGKTTLISQWAAGKNDIG WYSLDEGDNQQERFASYLIAAVQQATNGHCAICETMAQKRQYASLTSLFAQLFIELAEWH SPLYLVIDDYHLITNPVIHESMRFFIRHQPENLTLVVLSRNLPQLGIANLRVRDQLLEIG SQQLAFTHQEAKQFFDCRLSSPIEAAESSRICDDVSGWATALQLIALSARQNTHSAHKSA RRLAGINASHLSDYLVDEVLDNVDLATRHFLLKSAILRSMNDALITRVTGEENGQMRLEE IERQGLFLQRMDDTGEWFCYHPLFGNFLRQRCQWELAAELPEIHRAAAESWMAQGFPSEA IHHALAAGDALMLRDILLNHAWSLFNHSELSLLEESLKALPWDSLLENPQLVLLQAWLMQ SQHRYGEVNTLLARAEHEIKDIREDTMHAEFNALRAQVAINDGNPDEAERLAKLALEELP PGWFYSRIVATSVLGEVLHCKGELTRSLALMQQTEQMARQHDVWHYALWSLIQQSEILFA QGFLQTAWETQEKAFQLINEQHLEQLPMHEFLVRIRAQLLWAWARLDEAEASARSGIEVL SSYQPQQQLQCLAMLIQCSLARGDLDNARSQLNRLENLLGNGKYHSDWISNANKVRVIYW QMTGDKAAAANWLRHTAKPEFANNHFLQGQWRNIARAQILLGEFEPAEIVLEELNENARS LRLMSDLNRNLLLLNQLYWQAGRKSDAQRVLLDALKLANRTGFISHFVIEGEAMAQQLRQ LIQLNTLPELEQHRAQRILREINQHHRHKFAHFDENFVERLLNHPEVPELIRTSPLTQRE WQVLGLIYSGYSNEQIAGELEVAATTIKTHIRNLYQKLGVAHRQDAVQHAQQLLKMMGYG V
Number of residues	None
Molecular Weight	103117.49
Theoretical pI	6.47
GO Classification	Functions ATP binding DNA binding identical protein binding transcription factor activity, sequence-specific DNA binding trisaccharide binding Processes carbohydrate metabolic process positive regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of carbohydrate metabolic process Components
General Function	Trisaccharide binding
Specific Function	Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box): 5'-GGA[TG]GA-3'.
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	P06993
UniProtKB Entry Name
Cellular Location	Cytoplasmic
Gene sequence	>lcl\|BSEQ0011183\|HTH-type transcriptional regulator MalT (malT) ATGCTGATTCCGTCAAAACTAAGTCGTCCGGTTCGACTCGACCATACCGTGGTTCGTGAG CGCCTGCTGGCTAAACTTTCCGGCGCGAACAACTTCCGGCTGGCGCTGATCACGAGTCCT GCGGGCTACGGAAAGACCACCCTCATTTCCCAGTGGGCGGCAGGCAAAAACGATATCGGC TGGTACTCGCTGGATGAAGGTGATAACCAGCAAGAGCGTTTCGCCAGCTATCTCATTGCC GCCGTGCAGCAGGCAACCAACGGTCACTGTGCGATATGTGAGACGATGGCGCAAAAACGG CAATATGCCAGCCTGACGTCACTCTTCGCCCAGCTTTTCATTGAGCTGGCGGAATGGCAT AGCCCACTTTATCTGGTCATCGATGACTATCATCTGATCACTAATCCAGTGATCCACGAG TCAATGCGCTTCTTTATTCGCCATCAACCAGAAAATCTCACCCTGGTGGTGTTGTCACGC AACCTTCCGCAACTGGGCATTGCCAATCTGCGTGTTCGTGATCAACTGCTGGAAATTGGC AGTCAGCAACTGGCATTTACCCATCAGGAAGCGAAGCAGTTTTTTGATTGCCGTCTGTCA TCGCCGATTGAAGCCGCAGAAAGCAGTCGGATTTGCGATGACGTTTCCGGTTGGGCGACG GCACTACAGCTAATCGCCCTCTCCGCCCGGCAGAATACCCACTCAGCCCATAAGTCGGCA CGCCGCCTGGCGGGAATCAATGCCAGCCATCTTTCGGATTATCTGGTCGATGAGGTTTTG GATAACGTCGATCTCGCAACGCGCCATTTTCTGTTGAAAAGCGCCATTTTGCGCTCAATG AACGATGCCCTCATCACCCGTGTGACCGGCGAAGAAAACGGGCAAATGCGCCTCGAAGAG ATTGAGCGTCAGGGGCTGTTTTTACAGCGGATGGATGATACCGGCGAGTGGTTCTGCTAT CACCCGCTGTTTGGTAACTTCCTGCGCCAGCGCTGCCAGTGGGAACTGGCGGCGGAGCTG CCGGAAATCCACCGTGCCGCCGCAGAAAGCTGGATGGCCCAGGGATTTCCCAGCGAAGCA ATTCATCATGCGCTGGCGGCAGGCGATGCGCTGATGCTGCGCGATATTCTGCTTAATCAC GCCTGGAGTCTGTTCAACCATAGCGAACTGTCGCTGCTGGAAGAGTCGCTTAAGGCCCTG CCGTGGGACAGCTTGCTGGAAAATCCGCAGTTGGTGTTATTGCAGGCGTGGCTGATGCAA AGCCAACATCGCTACGGCGAAGTTAACACCCTGCTAGCCCGTGCTGAACATGAAATCAAG GACATCAGAGAAGACACCATGCACGCAGAATTTAACGCTCTGCGCGCCCAGGTGGCGATT AACGATGGTAATCCGGATGAAGCGGAACGGCTGGCAAAACTGGCACTGGAAGAGCTGCCG CCGGGCTGGTTCTATAGCCGCATTGTGGCAACCTCGGTGCTGGGTGAAGTGCTGCACTGC AAAGGCGAATTGACCCGCTCACTGGCGCTAATGCAGCAAACCGAACAGATGGCACGCCAG CACGATGTCTGGCACTACGCTTTGTGGAGTTTAATCCAGCAAAGTGAAATTCTGTTTGCC CAAGGGTTCCTGCAAACCGCGTGGGAAACGCAGGAAAAAGCATTCCAGCTGATCAACGAG CAGCATCTGGAACAGCTGCCAATGCATGAGTTTCTGGTGCGCATTCGTGCGCAGCTGTTA TGGGCCTGGGCGCGGCTGGATGAAGCCGAAGCGTCGGCGCGTAGCGGGATTGAAGTCTTG TCGTCTTATCAGCCACAGCAACAGCTTCAGTGCCTGGCAATGTTGATTCAATGCTCGCTG GCCCGTGGTGATTTAGATAACGCCCGTAGCCAGCTGAACCGTCTGGAAAACCTGCTGGGG AATGGCAAATATCACAGCGACTGGATCTCTAACGCCAACAAAGTCCGGGTGATTTACTGG CAAATGACCGGCGATAAAGCCGCCGCTGCCAACTGGTTGCGTCATACGGCTAAACCAGAG TTTGCGAACAACCACTTCCTGCAAGGTCAATGGCGCAACATTGCCCGTGCACAAATCTTG CTGGGCGAGTTTGAACCGGCAGAAATTGTTCTCGAAGAACTCAATGAAAATGCCCGGAGT CTGCGGTTGATGAGCGATCTCAACCGTAACCTGTTGCTGCTTAATCAACTGTACTGGCAG GCCGGACGTAAAAGTGACGCCCAGCGCGTGTTGCTGGACGCATTAAAACTGGCGAATCGC ACCGGATTTATCAGCCATTTTGTCATCGAAGGCGAAGCGATGGCGCAACAACTGCGTCAG CTGATTCAGCTTAATACGCTGCCGGAACTGGAACAGCATCGCGCGCAGCGTATTCTGCGA GAAATCAATCAACATCATCGGCATAAATTCGCCCATTTCGATGAGAATTTCGTTGAACGT CTGCTAAATCATCCTGAAGTACCTGAACTGATCCGCACCAGCCCGCTGACGCAACGTGAA TGGCAGGTACTGGGGCTGATCTACTCTGGTTACAGCAATGAGCAAATTGCCGGAGAACTG GAAGTCGCGGCAACCACCATCAAAACGCATATCCGCAATCTGTATCAGAAACTCGGCGTG GCCCATCGCCAGGATGCGGTACAACACGCCCAGCAATTGCTGAAGATGATGGGGTACGGC GTGTAA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Cole ST, Raibaud O: The nucleotide sequence of the malT gene encoding the positive regulator of the Escherichia coli maltose regulon. Gene. 1986;42(2):201-8. [3015733 ] Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [9278503 ] Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [16738553 ] Debarbouille M, Cossart P, Raibaud O: A DNA sequence containing the control sites for gene malT and for the malPQ operon. Mol Gen Genet. 1982;185(1):88-92. [6283313 ] Richet E, Raibaud O: MalT, the regulatory protein of the Escherichia coli maltose system, is an ATP-dependent transcriptional activator. EMBO J. 1989 Mar;8(3):981-7. [2524384 ] Schlegel A, Danot O, Richet E, Ferenci T, Boos W: The N terminus of the Escherichia coli transcription activator MalT is the domain of interaction with MalY. J Bacteriol. 2002 Jun;184(11):3069-77. [12003949 ] Steegborn C, Danot O, Huber R, Clausen T: Crystal structure of transcription factor MalT domain III: a novel helix repeat fold implicated in regulated oligomerization. Structure. 2001 Nov;9(11):1051-60. [11709169 ]

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