Hydroxyquinol 1,2-dioxygenase

Name	Hydroxyquinol 1,2-dioxygenase
Synonyms	1,2-HQD 1.13.11.37
Gene Name	chqB
Organism	Nocardioides simplex
Amino acid sequence	>lcl\|BSEQ0012217\|Hydroxyquinol 1,2-dioxygenase MSTPVSAEQQAREQDLVERVLRSFDATADPRLKQVMQALTRHLHAFLREVRLTEAEWETG IGFLTDAGHVTNERRQEFILLSDVLGASMQTIAMNNEAHGDATEATVFGPFFVEGSPRIE SGGDIAGGAAGEPCWVEGTVTDTDGNPVPDARIEVWEADDDGFYDVQYDDDRTAARAHLL SGPDGGYAFWAITPTPYPIPHDGPVGRMLAATGRSPMRASHLHFMVTAPGRRTLVTHIFV EGDELLDRDSVFGVKDSLVKSFERQPAGAPTPGGREIDGPWSRVRFDIVLAPA
Number of residues	None
Molecular Weight	31966.33
Theoretical pI	4.5
GO Classification	Functions ferric iron binding catechol 1,2-dioxygenase activity hydroxyquinol 1,2-dioxygenase activity Processes beta-ketoadipate pathway catechol-containing compound metabolic process Components
General Function	Hydroxyquinol 1,2-dioxygenase activity
Specific Function	Catalyzes the ortho-cleavage of the aromatic ring of hydroxyquinol.
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	Q5PXQ6
UniProtKB Entry Name
Cellular Location	None
Gene sequence	>lcl\|BSEQ0006199\|882 bp ATGAGCACGCCCGTCTCCGCCGAGCAGCAGGCCCGCGAGCAGGACCTGGTCGAGCGCGTG CTGCGCTCCTTCGACGCCACCGCCGACCCGCGCCTGAAGCAGGTGATGCAGGCGCTGACC CGGCACCTGCACGCCTTCCTGCGCGAGGTGCGGCTGACCGAGGCGGAGTGGGAGACCGGG ATCGGCTTCCTGACCGACGCCGGTCACGTCACCAACGAGCGACGCCAGGAGTTCATCCTG CTCTCCGACGTCCTCGGCGCGTCGATGCAGACGATCGCGATGAACAACGAGGCCCACGGC GACGCCACCGAGGCCACCGTCTTCGGACCGTTCTTCGTCGAGGGGTCGCCGCGGATCGAG TCCGGCGGTGACATCGCCGGTGGCGCGGCCGGCGAGCCGTGCTGGGTCGAGGGCACGGTC ACCGACACCGACGGCAACCCCGTGCCCGATGCGCGGATCGAGGTGTGGGAGGCCGACGAC GACGGCTTCTACGACGTCCAGTACGACGACGACCGCACCGCCGCGCGCGCCCACCTGCTC AGCGGCCCGGACGGAGGCTATGCGTTCTGGGCGATCACGCCGACCCCCTACCCGATCCCC CACGACGGGCCGGTCGGCCGGATGCTCGCCGCCACCGGCCGCTCCCCCATGCGCGCCTCG CACCTGCACTTCATGGTCACCGCGCCCGGGCGGCGCACGTTGGTCACGCACATCTTCGTC GAGGGCGACGAGCTGCTCGACCGCGACTCGGTGTTCGGCGTGAAGGACTCGCTTGTCAAG AGCTTCGAGCGGCAGCCGGCCGGCGCGCCCACTCCCGGCGGCCGCGAGATCGACGGCCCC TGGTCGCGGGTGCGCTTCGACATCGTCCTCGCTCCCGCCTGA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID
Chromosome Location	None
Locus	None
References	Ferraroni M, Seifert J, Travkin VM, Thiel M, Kaschabek S, Scozzafava A, Golovleva L, Schlomann M, Briganti F: Crystal structure of the hydroxyquinol 1,2-dioxygenase from Nocardioides simplex 3E, a key enzyme involved in polychlorinated aromatics biodegradation. J Biol Chem. 2005 Jun 3;280(22):21144-54. Epub 2005 Mar 16. [15772073 ] Travkin VM, Jadan AP, Briganti F, Scozzafava A, Golovleva LA: Characterization of an intradiol dioxygenase involved in the biodegradation of the chlorophenoxy herbicides 2,4-D and 2,4,5-T. FEBS Lett. 1997 Apr 21;407(1):69-72. [9141483 ]

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