3-methyl-2-oxobutanoate hydroxymethyltransferase

Name3-methyl-2-oxobutanoate hydroxymethyltransferase
Synonyms
  • 2.1.2.11
  • Ketopantoate hydroxymethyltransferase
  • KPHMT
Gene NamepanB
OrganismNeisseria meningitidis serogroup B (strain MC58)
Amino acid sequence
>lcl|BSEQ0011305|3-methyl-2-oxobutanoate hydroxymethyltransferase
MITVNTLQKMKAAGEKIAMLTAYESSFAALMDDAGVEMLLVGDSLGMAVQGRKSTLPVSL
RDMCYHTECVARGAKNAMIVSDLPFGAYQQSKEQAFAAAAELMAAGAHMVKLEGGVWMAE
TTEFLQMRGIPVCAHIGLTPQSVFAFGGYKVQGRGGKAQALLNDAKAHDDAGAAVVLMEC
VLAELAKKVTETVSCPTIGIGAGADCDGQVLVMHDMLGIFPGKTAKFVKNFMQGHDSVQA
AVRAYVAEVKAKTFPAAEHIFAD
Number of residuesNone
Molecular Weight27739.07
Theoretical pI6.39
GO Classification
Functions
  • metal ion binding
  • 3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Processes
  • pantothenate biosynthetic process
Components
  • cytoplasm
General FunctionMetal ion binding
Specific FunctionCatalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ9JZW6
UniProtKB Entry Name
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0011306|3-methyl-2-oxobutanoate hydroxymethyltransferase (panB)
ATGATTACTGTGAACACACTGCAAAAAATGAAGGCGGCGGGCGAAAAAATCGCTATGCTG
ACCGCTTACGAATCCAGTTTTGCCGCGCTGATGGACGATGCCGGCGTGGAAATGCTGCTG
GTCGGCGATTCTTTGGGGATGGCGGTTCAGGGGCGGAAATCGACGCTGCCCGTCAGCCTG
CGCGATATGTGTTATCACACCGAATGTGTAGCACGCGGTGCAAAAAATGCGATGATTGTC
AGCGATTTGCCGTTTGGTGCATATCAGCAGAGTAAGGAGCAGGCGTTTGCCGCCGCCGCC
GAACTGATGGCTGCCGGCGCGCATATGGTTAAACTCGAAGGCGGCGTGTGGATGGCGGAA
ACGACTGAATTTTTGCAAATGCGCGGTATTCCGGTTTGTGCGCACATCGGTCTGACCCCG
CAATCCGTGTTTGCCTTCGGCGGATATAAAGTTCAGGGGCGCGGCGGCAAGGCGCAGGCG
TTGCTTAACGATGCCAAGGCGCATGACGATGCGGGGGCGGCGGTCGTGCTGATGGAGTGC
GTACTGGCGGAACTGGCAAAAAAGGTAACTGAAACTGTTTCCTGTCCGACCATCGGCATC
GGCGCGGGTGCGGATTGCGACGGGCAGGTTTTGGTGATGCACGATATGCTCGGCATTTTC
CCGGGTAAGACGGCGAAATTCGTCAAAAACTTTATGCAGGGGCATGATAGTGTTCAAGCG
GCGGTTCGGGCGTATGTTGCCGAAGTCAAAGCCAAAACCTTCCCTGCTGCGGAACATATT
TTTGCAGATTGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome LocationNone
LocusNone
References
  1. Tettelin H, Saunders NJ, Heidelberg J, Jeffries AC, Nelson KE, Eisen JA, Ketchum KA, Hood DW, Peden JF, Dodson RJ, Nelson WC, Gwinn ML, DeBoy R, Peterson JD, Hickey EK, Haft DH, Salzberg SL, White O, Fleischmann RD, Dougherty BA, Mason T, Ciecko A, Parksey DS, Blair E, Cittone H, Clark EB, Cotton MD, Utterback TR, Khouri H, Qin H, Vamathevan J, Gill J, Scarlato V, Masignani V, Pizza M, Grandi G, Sun L, Smith HO, Fraser CM, Moxon ER, Rappuoli R, Venter JC: Complete genome sequence of Neisseria meningitidis serogroup B strain MC58. Science. 2000 Mar 10;287(5459):1809-15. [10710307 ]
  2. Badger J, Sauder JM, Adams JM, Antonysamy S, Bain K, Bergseid MG, Buchanan SG, Buchanan MD, Batiyenko Y, Christopher JA, Emtage S, Eroshkina A, Feil I, Furlong EB, Gajiwala KS, Gao X, He D, Hendle J, Huber A, Hoda K, Kearins P, Kissinger C, Laubert B, Lewis HA, Lin J, Loomis K, Lorimer D, Louie G, Maletic M, Marsh CD, Miller I, Molinari J, Muller-Dieckmann HJ, Newman JM, Noland BW, Pagarigan B, Park F, Peat TS, Post KW, Radojicic S, Ramos A, Romero R, Rutter ME, Sanderson WE, Schwinn KD, Tresser J, Winhoven J, Wright TA, Wu L, Xu J, Harris TJ: Structural analysis of a set of proteins resulting from a bacterial genomics project. Proteins. 2005 Sep 1;60(4):787-96. [16021622 ]

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