HTH-type transcriptional regulator TtgR

NameHTH-type transcriptional regulator TtgR
Synonyms
  • Toluene efflux pump ttgABC operon repressor
Gene NamettgR
OrganismPseudomonas putida (strain DOT-T1E)
Amino acid sequence
>lcl|BSEQ0012850|HTH-type transcriptional regulator TtgR
MVRRTKEEAQETRAQIIEAAERAFYKRGVARTTLADIAELAGVTRGAIYWHFNNKAELVQ
ALLDSLHETHDHLARASESEDEVDPLGCMRKLLLQVFNELVLDARTRRINEILHHKCEFT
DDMCEIRQQRQSAVLDCHKGITLALANAVRRGQLPGELDAERAAVAMFAYVDGLIRRWLL
LPDSVDLLGDVEKWVDTGLDMLRLSPALRK
Number of residuesNone
Molecular Weight23854.075
Theoretical pI6.17
GO Classification
Functions
  • DNA binding
Processes
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
Components
General FunctionDna binding
Specific FunctionRepresses expression from the ttgABC operon promoter and its own expression. Binds to a promoter region between the divergently transcribed ttgR and ttgABC genes/operons; in the presence of chloramphenicol or tetracycline this binding no longer occurs and ttgR and ttgABC are derepressed. This suggests that TtgR binds these antibiotics.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDQ9AIU0
UniProtKB Entry Name
Cellular LocationCytoplasmic
Gene sequence
>lcl|BSEQ0012851|HTH-type transcriptional regulator TtgR (ttgR)
ATGGTCCGTCGAACCAAAGAAGAAGCCCAGGAAACCCGTGCCCAGATCATCGAGGCGGCG
GAAAGGGCCTTCTACAAGCGCGGGGTTGCGCGAACCACCCTGGCCGACATCGCCGAACTG
GCGGGTGTGACGCGGGGGGCGATCTACTGGCACTTCAACAACAAGGCCGAGCTGGTGCAG
GCGTTGCTCGACAGCCTGCACGAGACCCATGACCATTTGGCGCGGGCGAGCGAAAGCGAG
GATGAAGTCGACCCGCTTGGCTGCATGCGCAAGCTGCTGTTGCAAGTGTTCAACGAGCTG
GTGCTCGATGCCCGAACCCGTCGTATCAATGAAATCCTGCATCACAAGTGCGAGTTCACC
GATGACATGTGTGAAATTCGCCAGCAGCGCCAGAGTGCGGTGCTGGATTGCCACAAGGGC
ATCACCCTGGCGCTGGCCAATGCCGTACGCCGGGGCCAGTTGCCTGGCGAGCTGGATGCC
GAGCGCGCGGCGGTGGCCATGTTTGCCTATGTCGATGGCCTGATCAGGCGCTGGCTATTG
CTGCCTGACAGTGTCGATCTGTTGGGTGATGTCGAAAAATGGGTCGACACCGGGCTGGAT
ATGCTGCGCTTGAGCCCGGCTCTGCGCAAATGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome LocationNone
LocusNone
References
  1. Duque E, Segura A, Mosqueda G, Ramos JL: Global and cognate regulators control the expression of the organic solvent efflux pumps TtgABC and TtgDEF of Pseudomonas putida. Mol Microbiol. 2001 Feb;39(4):1100-6. [11251828 ]
  2. Udaondo Z, Molina L, Daniels C, Gomez MJ, Molina-Henares MA, Matilla MA, Roca A, Fernandez M, Duque E, Segura A, Ramos JL: Metabolic potential of the organic-solvent tolerant Pseudomonas putida DOT-T1E deduced from its annotated genome. Microb Biotechnol. 2013 Sep;6(5):598-611. doi: 10.1111/1751-7915.12061. Epub 2013 Jul 1. [23815283 ]
  3. Teran W, Felipe A, Segura A, Rojas A, Ramos JL, Gallegos MT: Antibiotic-dependent induction of Pseudomonas putida DOT-T1E TtgABC efflux pump is mediated by the drug binding repressor TtgR. Antimicrob Agents Chemother. 2003 Oct;47(10):3067-72. [14506010 ]

From www.t3db.ca