Eukaryotic translation initiation factor 3 subunit F

NameEukaryotic translation initiation factor 3 subunit F
Synonyms
  • Deubiquitinating enzyme eIF3f
  • eIF-3-epsilon
  • eIF3 p47
  • eIF3f
  • EIF3S5
  • Eukaryotic translation initiation factor 3 subunit 5
Gene NameEIF3F
OrganismHuman
Amino acid sequence
>lcl|BSEQ0049747|Eukaryotic translation initiation factor 3 subunit F
MATPAVPVSAPPATPTPVPAAAPASVPAPTPAPAAAPVPAAAPASSSDPAAAAAATAAPG
QTPASAQAPAQTPAPALPGPALPGPFPGGRVVRLHPVILASIVDSYERRNEGAARVIGTL
LGTVDKHSVEVTNCFSVPHNESEDEVAVDMEFAKNMYELHKKVSPNELILGWYATGHDIT
EHSVLIHEYYSREAPNPIHLTVDTSLQNGRMSIKAYVSTLMGVPGRTMGVMFTPLTVKYA
YYDTERIGVDLIMKTCFSPNRVIGLSSDLQQVGGASARIQDALSTVLQYAEDVLSGKVSA
DNTVGRFLMSLVNQVPKIVPDDFETMLNSNINDLLMVTYLANLTQSQIALNEKLVNL
Number of residuesNone
Molecular Weight37563.48
Theoretical pINone
GO Classification
Functions
  • translation initiation factor activity
  • translation initiation factor binding
  • thiol-dependent ubiquitin-specific protease activity
Processes
  • translational initiation
  • protein deubiquitination
  • IRES-dependent viral translational initiation
Components
  • membrane
  • cytosol
  • eukaryotic translation initiation factor 3 complex
  • eukaryotic translation initiation factor 3 complex, eIF3m
General FunctionComponent of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
Specific FunctionThiol-dependent ubiquitin-specific protease activity
Transmembrane Regions
GenBank Protein ID
UniProtKB IDO00303
UniProtKB Entry Name
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0049748|Eukaryotic translation initiation factor 3 subunit F (EIF3F)
ATGGCCACACCGGCGGTACCAGTAAGTGCTCCTCCGGCCACGCCAACCCCAGTCCCGGCG
GCGGCCCCAGCCTCAGTTCCAGCGCCAACGCCAGCACCGGCTGCGGCTCCGGTTCCCGCT
GCGGCTCCAGCCTCATCCTCAGACCCTGCGGCAGCAGCGGCTGCAACTGCGGCTCCTGGC
CAGACCCCGGCCTCAGCGCAAGCTCCAGCGCAGACCCCAGCGCCCGCTCTGCCTGGTCCT
GCTCTTCCAGGGCCCTTCCCCGGCGGCCGCGTGGTCAGGCTGCACCCAGTCATTTTGGCC
TCCATTGTGGACAGCTACGAGAGACGCAACGAGGGTGCTGCCCGAGTTATCGGGACCCTG
TTGGGAACTGTCGACAAACACTCAGTGGAGGTCACCAATTGCTTTTCAGTGCCGCACAAT
GAGTCAGAAGATGAAGTGGCTGTTGACATGGAATTTGCTAAGAATATGTATGAACTGCAT
AAAAAAGTTTCTCCAAATGAGCTCATCCTGGGCTGGTACGCTACGGGCCATGACATCACA
GAGCACTCTGTGCTGATCCACGAGTACTACAGCCGAGAGGCCCCCAACCCCATCCACCTC
ACTGTGGACACAAGTCTCCAGAACGGCCGCATGAGCATCAAAGCCTACGTCAGCACTTTA
ATGGGAGTCCCTGGGAGGACCATGGGAGTGATGTTCACGCCTCTGACAGTGAAATACGCG
TACTACGACACTGAACGCATCGGAGTTGACCTGATCATGAAGACCTGCTTTAGCCCCAAC
AGAGTGATTGGACTCTCAAGTGACTTGCAGCAAGTAGGAGGGGCATCAGCTCGCATCCAG
GATGCCCTGAGTACAGTGTTGCAATATGCAGAGGATGTACTGTCTGGAAAGGTGTCAGCT
GACAATACTGTGGGCCGCTTCCTGATGAGCCTGGTTAACCAAGTACCGAAAATAGTTCCC
GATGACTTTGAGACCATGCTCAACAGCAACATCAATGACCTTTTGATGGTGACCTACCTG
GCCAACCTCACACAGTCACAGATTGCACTCAATGAAAAACTTGTAAACCTGTGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC ID
Chromosome Location11
Locus11p15.4
References
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From www.t3db.ca