G2/mitotic-specific cyclin-B1


NameG2/mitotic-specific cyclin-B1
Synonyms
  • CCNB
Gene NameCCNB1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009795|G2/mitotic-specific cyclin-B1
MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKM
PMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSPEPI
LVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQ
LEEEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVP
KKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRP
LPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGE
WTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNS
ALVQDLAKAVAKV
Number of residues433
Molecular Weight48337.06
Theoretical pINone
GO Classification
Functions
  • patched binding
  • protein kinase binding
  • histone kinase activity
Processes
  • response to drug
  • positive regulation of fibroblast proliferation
  • response to mechanical stimulus
  • ventricular cardiac muscle cell development
  • cellular response to organic cyclic compound
  • regulation of cell cycle
  • mitotic metaphase plate congression
  • positive regulation of mitotic cell cycle
  • digestive tract development
  • cell division
  • positive regulation of attachment of spindle microtubules to kinetochore
  • G1/S transition of mitotic cell cycle
  • positive regulation of cardiac muscle cell proliferation
  • protein complex assembly
  • negative regulation of gene expression
  • oocyte maturation
  • in utero embryonic development
  • tissue regeneration
  • mitotic nuclear envelope disassembly
  • cellular response to iron(III) ion
  • spermatogenesis
  • negative regulation of protein phosphorylation
  • histone H3-S10 phosphorylation involved in chromosome condensation
  • regulation of mitotic cell cycle spindle assembly checkpoint
  • mitotic spindle stabilization
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • cellular response to fatty acid
  • G2/M transition of mitotic cell cycle
  • positive regulation of mRNA 3'-end processing
  • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  • positive regulation of histone phosphorylation
  • mitotic cell cycle
  • regulation of chromosome condensation
  • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  • cellular response to hypoxia
  • response to DDT
Components
  • centrosome
  • condensed nuclear chromosome outer kinetochore
  • cytosol
  • nucleoplasm
  • spindle pole
  • cytoplasm
  • membrane
  • nucleus
General FunctionProtein kinase binding
Specific FunctionEssential for the control of the cell cycle at the G2/M (mitosis) transition.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP14635
UniProtKB Entry NameCCNB1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0013916|G2/mitotic-specific cyclin-B1 (CCNB1)
ATGGCGCTCCGAGTCACCAGGAACTCGAAAATTAATGCTGAAAATAAGGCGAAGATCAAC
ATGGCAGGCGCAAAGCGCGTTCCTACGGCCCCTGCTGCAACCTCCAAGCCCGGACTGAGG
CCAAGAACAGCTCTTGGGGACATTGGTAACAAAGTCAGTGAACAACTGCAGGCCAAAATG
CCTATGAAGAAGGAAGCAAAACCTTCAGCTACTGGAAAAGTCATTGATAAAAAACTACCA
AAACCTCTTGAAAAGGTACCTATGCTGGTGCCAGTGCCAGTGTCTGAGCCAGTGCCAGAG
CCAGAACCTGAGCCAGAACCTGAGCCTGTTAAAGAAGAAAAACTTTCGCCTGAGCCTATT
TTGGTTGATACTGCCTCTCCAAGCCCAATGGAAACATCTGGATGTGCCCCTGCAGAAGAA
GACCTGTGTCAGGCTTTCTCTGATGTAATTCTTGCAGTAAATGATGTGGATGCAGAAGAT
GGAGCTGATCCAAACCTTTGTAGTGAATATGTGAAAGATATTTATGCTTATCTGAGACAA
CTTGAGGAAGAGCAAGCAGTCAGACCAAAATACCTACTGGGTCGGGAAGTCACTGGAAAC
ATGAGAGCCATCCTAATTGACTGGCTAGTACAGGTTCAAATGAAATTCAGGTTGTTGCAG
GAGACCATGTACATGACTGTCTCCATTATTGATCGGTTCATGCAGAATAATTGTGTGCCC
AAGAAGATGCTGCAGCTGGTTGGTGTCACTGCCATGTTTATTGCAAGCAAATATGAAGAA
ATGTACCCTCCAGAAATTGGTGACTTTGCTTTTGTGACTGACAACACTTATACTAAGCAC
CAAATCAGACAGATGGAAATGAAGATTCTAAGAGCTTTAAACTTTGGTCTGGGTCGGCCT
CTACCTTTGCACTTCCTTCGGAGAGCATCTAAGATTGGAGAGGTTGATGTCGAGCAACAT
ACTTTGGCCAAATACCTGATGGAACTAACTATGTTGGACTATGACATGGTGCACTTTCCT
CCTTCTCAAATTGCAGCAGGAGCTTTTTGCTTAGCACTGAAAATTCTGGATAATGGTGAA
TGGACACCAACTCTACAACATTACCTGTCATATACTGAAGAATCTCTTCTTCCAGTTATG
CAGCACCTGGCTAAGAATGTAGTCATGGTAAATCAAGGACTTACAAAGCACATGACTGTC
AAGAACAAGTATGCCACATCGAAGCATGCTAAGATCAGCACTCTACCACAGCTGAATTCT
GCACTAGTTCAAGATTTAGCCAAGGCTGTGGCAAAGGTGTAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:1579
Chromosome Location5
LocusNone
References
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