Lysine-specific demethylase 4E

Name	Lysine-specific demethylase 4E
Synonyms	1.14.11.- KDM4D-like protein KDM4DL Lysine-specific demethylase 4D-like
Gene Name	KDM4E
Organism	Human
Amino acid sequence	>lcl\|BSEQ0020895\|Lysine-specific demethylase 4E MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMY DDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQ RYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFG MWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQHLERLARELFPDISRGCEAFLR HKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDY GKMASQCSCGESTVTFSMDPFVRIVQPESYELWKHRQDLAIVEHTEPRVAESQELSNWRD DIVLRRAALGLRLLPNLTAQCPTQPVSSGHCYNPKGCGTDAVPGSAFQSSAYHTQTQSLT LGMSARVLLPSTGSWGSGRGRGRGQGQGRGCSRGRGHGCCTRELGTEEPTVQPASKRRLL MGTRSRAQGHRPQLPLANDLMTNLSL
Number of residues	506
Molecular Weight	56803.925
Theoretical pI	None
GO Classification	Functions dioxygenase activity metal ion binding Processes regulation of transcription, DNA-templated transcription, DNA-templated chromatin modification Components nucleus
General Function	Metal ion binding
Specific Function	Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
Transmembrane Regions
GenBank Protein ID
UniProtKB ID	B2RXH2
UniProtKB Entry Name	KDM4E_HUMAN
Cellular Location	Nucleus
Gene sequence	>lcl\|BSEQ0020896\|Lysine-specific demethylase 4E (KDM4E) ATGAAGTCTGTGCACTCCAGTCCCCAGAACACGAGTCATACCATCATGACGTTTTACCCA ACCATGGAAGAATTTGCAGATTTCAACACATATGTTGCTTACATGGAGTCCCAAGGCGCA CATCAAGCTGGCCTTGCCAAGGTAATTCCACCCAAGGAATGGAAAGCCAGACAGATGTAT GATGATATCGAAGACATCTTAATAGCCACTCCCCTCCAGCAGGTGACCTCTGGGCAGGGA GGTGTGTTTACTCAATACCATAAAAAGAAGAAAGCCATGAGGGTGGGGCAGTATCGCCGC TTGGCAAACAGTAAAAAATATCAGACTCCGCCACACCAGAATTTTGCAGATTTGGAGCAA CGATACTGGAAGAGCCACCCCGGTAATCCACCAATTTATGGTGCTGATATCAGCGGCTCC TTATTTGAAGAAAGCACTAAACAATGGAACCTAGGACACCTGGGAACAATTCTGGACCTG TTGGAGCAGGAATGTGGGGTTGTCATCGAGGGTGTCAACACACCCTACCTGTACTTTGGC ATGTGGAAGACCACGTTTGCCTGGCACACAGAGGACATGGACCTTTACAGCATCAACTAC CTGCACTTTGGGGAGCCCAAAACTTGGTACGTGGTGCCCCCAGAACATGGTCAGCACCTG GAACGCCTGGCCAGGGAGCTCTTCCCAGACATTTCTCGGGGCTGTGAGGCCTTCCTGCGG CACAAAGTGGCCCTCATCTCGCCTACAGTTCTCAAGGAAAATGGGATTCCCTTCAATTGC ATGACTCAGGAGGCTGGGGAGTTCATGGTGACCTTTCCCTATGGCTACCATGCTGGCTTC AATCACGGCTTCAACTGCGCAGAAGCCATTAATTTTGCCACTCCACGATGGATTGATTAT GGCAAAATGGCCTCTCAGTGTAGCTGTGGGGAGTCGACAGTGACCTTTTCCATGGACCCC TTTGTGCGCATTGTGCAACCCGAGAGTTATGAGCTCTGGAAACACAGGCAAGACTTGGCC ATTGTGGAACACACAGAGCCCAGGGTTGCAGAAAGCCAAGAGCTGAGCAACTGGAGAGAT GATATAGTACTTAGAAGAGCTGCTCTGGGCCTGAGGCTTCTCCCAAACCTCACAGCCCAG TGTCCCACACAGCCTGTGTCCTCAGGGCACTGTTACAACCCAAAAGGCTGTGGCACTGAT GCTGTGCCTGGATCCGCATTCCAAAGCTCTGCATATCATACCCAGACCCAGTCACTTACC CTGGGGATGTCAGCCAGGGTTCTTCTCCCTTCCACTGGAAGCTGGGGTTCTGGTCGTGGT CGTGGTCGTGGTCAAGGTCAAGGTCGAGGTTGCAGTCGTGGTCGTGGTCATGGTTGTTGT ACTCGAGAACTGGGGACTGAGGAGCCAACTGTTCAGCCTGCATCCAAGAGGCGCCTTTTA ATGGGTACAAGGAGTAGAGCTCAAGGCCACAGGCCTCAGCTCCCGCTTGCCAATGATTTG ATGACAAATCTGTCCCTTTGA
GenBank Gene ID
GeneCard ID	None
GenAtlas ID
HGNC ID	HGNC:37098
Chromosome Location	11
Locus	None
References	Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500.[16554811 ] Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ] Hillringhaus L, Yue WW, Rose NR, Ng SS, Gileadi C, Loenarz C, Bello SH, Bray JE, Schofield CJ, Oppermann U: Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family. J Biol Chem. 2011 Dec 2;286(48):41616-25. doi: 10.1074/jbc.M111.283689. Epub 2011 Sep 13.[21914792 ]

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