EC number:1.1.1.138
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.138 | ||
|---|---|---|---|
| Description: | Mannitol 2-dehydrogenase (NADP(+)). | ||
| Alternative Name: |
NADP-dependent mannitol dehydrogenase. | ||
| Prosite: | PDOC00060; | ||
| PDB: |
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| Cath: | 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.138 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.138 |
| KEGG Enzyme Link: | KEGG1.1.1.138 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.138 |
| ExPASy Enzyme Link: | ExPASy1.1.1.138 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.138 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.138 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.138 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.138 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.138 |
EC number:1.1.1.138
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:16765 | D-mannitol + NADP(+) = D-fructose + H(+) + NADPH |
| RULE(radius=1) | ([*:1]-[CH;+0:2](-[*:3])-[*:4].[*:5]-[OH;+0:6]).[*:7]-[n+;H0:8]1:[cH;+0:9]:[cH;+0:10]:[cH;+0:11]:[c;H0;+0:12](-[*:13]):[cH;+0:14]:1>>[*:7]-[N;H0;+0:8]1-[CH;+0:9]=[CH;+0:10]-[CH2;+0:11]-[C;H0;+0:12](-[*:13])=[CH;+0:14]-1.[*:5]-[O;H0;+0:6]-[C;H0;+0:2](-[*:1])(-[*:3])-[*:4] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Yarrowia lipolytica dehydrogenase/reductase: an enzyme tolerant for lipophilic compounds and carbohydrate substrates. | Napora K, Wrodnigg TM, Kosmus P, Thonhofer M, Robins K, Winkler M | 2013 Jun 1 | 23608762 |
| The Hypocrea jecorina (syn. Trichoderma reesei) lxr1 gene encodes a D-mannitol dehydrogenase and is not involved in L-arabinose catabolism. | Metz B, de Vries RP, Polak S, Seidl V, Seiboth B | 2009 Apr 17 | 19303876 |
| Identification and characterization of the Tuber borchii D-mannitol dehydrogenase which defines a new subfamily within the polyol-specific medium chain dehydrogenases. | Ceccaroli P, Saltarelli R, Guescini M, Polidori E, Buffalini M, Menotta M, Pierleoni R, Barbieri E, Stocchi V | 2007 Oct | 17317242 |
| Alternaria alternata NADP-dependent mannitol dehydrogenase is an important fungal allergen. | Schneider PB, Denk U, Breitenbach M, Richter K, Schmid-Grendelmeier P, Nobbe S, Himly M, Mari A, Ebner C, Simon-Nobbe B | 2006 Dec | 17177674 |
| Purification and characterization of a novel mannitol dehydrogenase from a newly isolated strain of Candida magnoliae. | Lee JK, Koo BS, Kim SY, Hyun HH | 2003 Aug | 12902227 |