EC number:1.1.1.145
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.145 |
|---|---|
| Description: | 3-beta-hydroxy-Delta(5)-steroid dehydrogenase. |
| Alternative Name: |
Progesterone reductase. 3-beta-hydroxy-5-ene steroid dehydrogenase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.145 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.145 |
| KEGG Enzyme Link: | KEGG1.1.1.145 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.145 |
| ExPASy Enzyme Link: | ExPASy1.1.1.145 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.145 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.145 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.145 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.145 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.145 |
EC number:1.1.1.145
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:43932 | 3beta-hydroxyandrost-5-en-17-one + NAD(+) = androst-5-ene-3,17-dione + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase. | Yang X, Dubnau E, Smith I, Sampson NS | 2007 Aug 7 | 17630785 |
| A novel missense mutation in the HSD3B2 gene, underlying nonsalt-wasting congenital adrenal hyperplasia. new insight into the structure-function relationships of 3β-hydroxysteroid dehidrogenase type II. | Baquedano MS, Ciaccio M, Marino R, Perez Garrido N, Ramirez P, Maceiras M, Turjanski A, Defelipe LA, Rivarola MA, Belgorosky A | 2015 Jan | 25322271 |
| Characterization, expression, and immunohistochemical localization of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in human skin. | Dumont M, Luu-The V, Dupont E, Pelletier G, Labrie F | 1992 Oct | 1401999 |
| RHEA:24076 | a 3beta-hydroxy-Delta(5)-steroid + NAD(+) = a 3-oxo-Delta(5)-steroid + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase. | Yang X, Dubnau E, Smith I, Sampson NS | 2007 Aug 7 | 17630785 |
| Purification and properties of 3-beta-hydroxysteroid dehydrogenase and delta-5-3-ketosteroid isomerase from bovine corpora lutea. | Cheatum SG, Watten JC | 1966 Jul 6 | 4226148 |
| THE CONVERSION OF PREGNENOLONE TO PROGESTERONE BY SMALL PARTICLES FROM RAT ADRENAL. | KORITZ SB | 1964 Aug | 14220672 |