EC number:1.1.1.153
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.153 |
|---|---|
| Description: | Sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming). |
| Cath: | 1.10.286.10; 3.30.1130.10; 3.30.479.10; 3.40.50.720; 3.10.270.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.153 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.153 |
| KEGG Enzyme Link: | KEGG1.1.1.153 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.153 |
| ExPASy Enzyme Link: | ExPASy1.1.1.153 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.153 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.153 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.153 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.153 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.153 |
EC number:1.1.1.153
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:32627 | (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[OH;+0:3])-[CH;+0:4](-[*:5])-[OH;+0:6].[*:7]-[c;H0;+0:8]1:[cH;+0:9]:[cH;+0:10]:[cH;+0:11]:[n+;H0:12](-[*:13]):[cH;+0:14]:1.[*:15]-[n+;H0:16]1:[cH;+0:17]:[cH;+0:18]:[cH;+0:19]:[c;H0;+0:20](-[*:21]):[cH;+0:22]:1>>[*:1]-[C;H0;+0:2](=[O;H0;+0:3])-[C;H0;+0:4](-[*:5])=[O;H0;+0:6].[*:7]-[C;H0;+0:8]1=[CH;+0:14]-[N;H0;+0:12](-[*:13])-[CH;+0:11]=[CH;+0:10]-[CH2;+0:9]-1.[*:15]-[N;H0;+0:16]1-[CH;+0:17]=[CH;+0:18]-[CH2;+0:19]-[C;H0;+0:20](-[*:21])=[CH;+0:22]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters. | Auerbach G, Herrmann A, Gütlich M, Fischer M, Jacob U, Bacher A, Huber R | 1997 Dec 15 | 9405351 |
| Synthesis and characterization of 3H-labelled tetrahydrobiopterin. | Werner ER, Schmid M, Werner-Felmayer G, Mayer B, Wachter H | 1994 Nov 15 | 7528005 |
| Purification and characterization of sepiapterin reductase from rat erythrocytes. | Sueoka T, Katoh S | 1982 Aug 6 | 7052139 |
| Sepiapterin reductase exhibits a NADPH-dependent dicarbonyl reductase activity. | Katoh S, Sueoka T | 1984 Feb 14 | 6200109 |
| Carbonyl reductase activity of sepiapterin reductase from rat erythrocytes. | Sueoka T, Katoh S | 1985 Dec 13 | 3904835 |
| Expression, purification, crystallization and preliminary X-ray analysis of sepiapterin reductase from Chlorobium tepidum. | Supangat S, Choi YK, Park YS, Son D, Han CD, Lee KH | 2005 Feb 1 | 16510994 |
| Structure of Chlorobium tepidum sepiapterin reductase complex reveals the novel substrate binding mode for stereospecific production of L-threo-tetrahydrobiopterin. | Supangat S, Seo KH, Choi YK, Park YS, Son D, Han CD, Lee KH | 2006 Jan 27 | 16308317 |
| Characterization of recombinant Dictyostelium discoideum sepiapterin reductase expressed in E. coli. | Kim YA, Chung HJ, Kim YJ, Choi YK, Hwang YK, Lee SW, Park YS | 2000 Aug 31 | 10987137 |
| RHEA:18953 | L-erythro-7,8-dihydrobiopterin + NADP(+) = H(+) + NADPH + sepiapterin |
| RULE(radius=1) | ([*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]:[n;H0;+0:6]:[*:7]:[nH;+0:8]:[*:9]).[*:10]-[n+;H0:11]1:[cH;+0:12]:[cH;+0:13]:[cH;+0:14]:[c;H0;+0:15](-[*:16]):[cH;+0:17]:1>>([*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]:[nH;+0:6]:[*:7]:[n;H0;+0:8]:[*:9]).[*:10]-[N;H0;+0:11]1-[CH;+0:12]=[CH;+0:13]-[CH2;+0:14]-[C;H0;+0:15](-[*:16])=[CH;+0:17]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters. | Auerbach G, Herrmann A, Gütlich M, Fischer M, Jacob U, Bacher A, Huber R | 1997 Dec 15 | 9405351 |
| Synthesis and characterization of 3H-labelled tetrahydrobiopterin. | Werner ER, Schmid M, Werner-Felmayer G, Mayer B, Wachter H | 1994 Nov 15 | 7528005 |
| Purification and characterization of sepiapterin reductase from rat erythrocytes. | Sueoka T, Katoh S | 1982 Aug 6 | 7052139 |
| Sepiapterin reductase exhibits a NADPH-dependent dicarbonyl reductase activity. | Katoh S, Sueoka T | 1984 Feb 14 | 6200109 |
| Carbonyl reductase activity of sepiapterin reductase from rat erythrocytes. | Sueoka T, Katoh S | 1985 Dec 13 | 3904835 |
| Expression, purification, crystallization and preliminary X-ray analysis of sepiapterin reductase from Chlorobium tepidum. | Supangat S, Choi YK, Park YS, Son D, Han CD, Lee KH | 2005 Feb 1 | 16510994 |
| Structure of Chlorobium tepidum sepiapterin reductase complex reveals the novel substrate binding mode for stereospecific production of L-threo-tetrahydrobiopterin. | Supangat S, Seo KH, Choi YK, Park YS, Son D, Han CD, Lee KH | 2006 Jan 27 | 16308317 |
| Mutational analysis of sites in sepiapterin reductase phosphorylated by Ca2+/calmodulin-dependent protein kinase II. | Fujimoto K, Takahashi SY, Katoh S | 2002 Jan 31 | 11825621 |
| Characterization of recombinant Dictyostelium discoideum sepiapterin reductase expressed in E. coli. | Kim YA, Chung HJ, Kim YJ, Choi YK, Hwang YK, Lee SW, Park YS | 2000 Aug 31 | 10987137 |