EC number:1.1.1.157
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.157 | ||
|---|---|---|---|
| Description: | 3-hydroxybutyryl-CoA dehydrogenase. | ||
| Alternative Name: |
BHBD. Beta-hydroxybutyryl-CoA dehydrogenase. | ||
| Prosite: | PDOC00065; | ||
| PDB: |
|
||
| Cath: | 1.10.1040.10; 1.10.1040.50; 3.30.750.190; 3.40.50.720; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.157 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.157 |
| KEGG Enzyme Link: | KEGG1.1.1.157 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.157 |
| ExPASy Enzyme Link: | ExPASy1.1.1.157 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.157 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.157 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.157 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.157 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.157 |
EC number:1.1.1.157
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:16197 | (3S)-hydroxybutanoyl-CoA + NADP(+) = acetoacetyl-CoA + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[c;H0;+0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[n+;H0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[C;H0;+0:6]1=[CH;+0:12]-[N;H0;+0:10](-[*:11])-[CH;+0:9]=[CH;+0:8]-[CH2;+0:7]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning, sequencing, and expression of clustered genes encoding beta-hydroxybutyryl-coenzyme A (CoA) dehydrogenase, crotonase, and butyryl-CoA dehydrogenase from Clostridium acetobutylicum ATCC 824. | Boynton ZL, Bennet GN, Rudolph FB | 1996 Jun | 8655474 |
| Purification and properties of NADP-dependent L(+)-3-hydroxybutyryl-CoA dehydrogenase from Clostridium kluyveri. | Madan VK, Hillmer P, Gottschalk G | 1973 Jan 3 | 4405720 |
| Characterization of a beta-hydroxybutyryl-CoA dehydrogenase from Mycobacterium tuberculosis. | Taylor RC, Brown AK, Singh A, Bhatt A, Besra GS | 2010 Jul | 20378648 |