EC number:1.1.1.178
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.178 | ||
|---|---|---|---|
| Description: | 3-hydroxy-2-methylbutyryl-CoA dehydrogenase. | ||
| Alternative Name: |
2-methyl-3-hydroxybutyryl-CoA dehydrogenase. | ||
| Prosite: | PDOC00060; | ||
| PDB: |
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| Cath: | 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.178 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.178 |
| KEGG Enzyme Link: | KEGG1.1.1.178 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.178 |
| ExPASy Enzyme Link: | ExPASy1.1.1.178 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.178 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.178 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.178 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.178 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.178 |
EC number:1.1.1.178
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:13281 | (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[c;H0;+0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[n+;H0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[C;H0;+0:6]1=[CH;+0:12]-[N;H0;+0:10](-[*:11])-[CH;+0:9]=[CH;+0:8]-[CH2;+0:7]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| D- and L-isoleucine metabolism and regulation of their pathways in Pseudomonas putida. | Conrad RS, Massey LK, Sokatch JR | 1974 Apr | 4150713 |
| Mental retardation linked to mutations in the HSD17B10 gene interfering with neurosteroid and isoleucine metabolism. | Yang SY, He XY, Olpin SE, Sutton VR, McMenamin J, Philipp M, Denman RB, Malik M | 2009 Sep 1 | 19706438 |
| Expanded substrate screenings of human and Drosophila type 10 17beta-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: characterization of multifunctional 3alpha/7alpha/7beta/17beta/20beta/21-HSD. | Shafqat N, Marschall HU, Filling C, Nordling E, Wu XQ, Björk L, Thyberg J, Mårtensson E, Salim S, Jörnvall H, Oppermann U | 2003 Nov 15 | 12917011 |