EC number:1.1.1.187
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.187 |
|---|---|
| Description: | GDP-4-dehydro-D-rhamnose reductase. |
| Alternative Name: |
Guanosine diphosphate-4-keto-D-rhamnose reductase. GDP-4-keto-D-rhamnose reductase. GDP-4-keto-6-deoxy-D-mannose reductase. |
| Cath: | 3.40.50.720; 3.90.25.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.187 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.187 |
| KEGG Enzyme Link: | KEGG1.1.1.187 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.187 |
| ExPASy Enzyme Link: | ExPASy1.1.1.187 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.187 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.187 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.187 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.187 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.187 |
EC number:1.1.1.187
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:10724 | GDP-6-deoxy-alpha-D-talose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Guanosine diphosphate-4-keto-D-rhamnose reductase. A non-stereoselective enzyme. | Winkler NW, Markovitz A | 1971 Oct 10 | 4398966 |
| The synthesis of guanosine 5'-diphosphate D-rhamnose by enzymes of a higher plant. | Barber GA | 1968 Aug 6 | 4386238 |
| BIOSYNTHESIS OF GUANOSINE DIPHOSPHATE D-RHAMNOSE AND GUANOSINE DIPHOSPHATE D-TALOMETHYLOSE FROM GUANOSINE DIPHOSPHATE ALPHA-D-MANNOSE. | MARKOVITZ A | 1964 Jul | 14209931 |
| RHEA:10728 | GDP-6-deoxy-alpha-D-talose + NAD(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Guanosine diphosphate-4-keto-D-rhamnose reductase. A non-stereoselective enzyme. | Winkler NW, Markovitz A | 1971 Oct 10 | 4398966 |
| The synthesis of guanosine 5'-diphosphate D-rhamnose by enzymes of a higher plant. | Barber GA | 1968 Aug 6 | 4386238 |
| BIOSYNTHESIS OF GUANOSINE DIPHOSPHATE D-RHAMNOSE AND GUANOSINE DIPHOSPHATE D-TALOMETHYLOSE FROM GUANOSINE DIPHOSPHATE ALPHA-D-MANNOSE. | MARKOVITZ A | 1964 Jul | 14209931 |
| RHEA:13825 | GDP-alpha-D-rhamnose + NAD(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Guanosine diphosphate-4-keto-D-rhamnose reductase. A non-stereoselective enzyme. | Winkler NW, Markovitz A | 1971 Oct 10 | 4398966 |
| The synthesis of guanosine 5'-diphosphate D-rhamnose by enzymes of a higher plant. | Barber GA | 1968 Aug 6 | 4386238 |
| Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose. | Mäki M, Järvinen N, Räbinä J, Roos C, Maaheimo H, Renkonen R, Pirkko., Mattila. | 2002 Jan | 11856318 |
| Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus L420-91T. | Kneidinger B, Graninger M, Adam G, Puchberger M, Kosma P, Zayni S, Messner P | 2001 Feb 23 | 11096116 |
| RHEA:13829 | GDP-alpha-D-rhamnose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Guanosine diphosphate-4-keto-D-rhamnose reductase. A non-stereoselective enzyme. | Winkler NW, Markovitz A | 1971 Oct 10 | 4398966 |
| The synthesis of guanosine 5'-diphosphate D-rhamnose by enzymes of a higher plant. | Barber GA | 1968 Aug 6 | 4386238 |
| Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose. | Mäki M, Järvinen N, Räbinä J, Roos C, Maaheimo H, Renkonen R, Pirkko., Mattila. | 2002 Jan | 11856318 |
| Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus L420-91T. | Kneidinger B, Graninger M, Adam G, Puchberger M, Kosma P, Zayni S, Messner P | 2001 Feb 23 | 11096116 |