EC number:1.1.1.188
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.188 | ||
|---|---|---|---|
| Description: | Prostaglandin-F synthase. | ||
| Alternative Name: |
Prostaglandin-F synthetase. Prostaglandin-D(2) ketoreductase. Prostaglandin-D(2) 11-reductase. Prostaglandin-D(2) 11-ketoreductase. Prostaglandin 11-ketoreductase. PGF synthetase. PGD(2) 11-ketoreductase. | ||
| Prosite: | PDOC00061; | ||
| PDB: |
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| Cath: | 3.20.20.10; 3.20.20.100; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.188 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.188 |
| KEGG Enzyme Link: | KEGG1.1.1.188 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.188 |
| ExPASy Enzyme Link: | ExPASy1.1.1.188 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.188 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.188 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.188 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.188 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.188 |
EC number:1.1.1.188
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:10140 | NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin D2 |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characteristics of a highly labile human type 5 17beta-hydroxysteroid dehydrogenase. | Dufort I, Rheault P, Huang XF, Soucy P, Luu-The V | 1999 Feb | 9927279 |
| Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular distribution. | Lin HK, Jez JM, Schlegel BP, Peehl DM, Pachter JA, Penning TM | 1997 Dec | 9415401 |
| Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases. | Khanna M, Qin KN, Wang RW, Cheng KC | 1995 Aug 25 | 7650035 |
| Prostaglandin production from arachidonic acid and evidence for a 9,11-endoperoxide prostaglandin H2 reductase in Leishmania. | Kabututu Z, Martin SK, Nozaki T, Kawazu S, Okada T, Munday CJ, Duszenko M, Lazarus M, Thuita LW, Urade Y, Kubata BK | 2003 Feb | 12633659 |
| Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3). | Penning TM, Burczynski ME, Jez JM, Lin HK, Ma H, Moore M, Ratnam K, Palackal N | 2001 Jan 22 | 11165022 |
| Identification of a novel prostaglandin f(2alpha) synthase in Trypanosoma brucei. | Kubata BK, Duszenko M, Kabututu Z, Rawer M, Szallies A, Fujimori K, Inui T, Nozaki T, Yamashita K, Horii T, Urade Y, Hayaishi O | 2000 Nov 6 | 11067881 |
| cDNA cloning, expression and characterization of human prostaglandin F synthase. | Suzuki-Yamamoto T, Nishizawa M, Fukui M, Okuda-Ashitaka E, Nakajima T, Ito S, Watanabe K | 1999 Dec 3 | 10622721 |