EC number:1.1.1.197

Enzyme

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EC Tree
     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.197
Description:15-hydroxyprostaglandin dehydrogenase (NADP(+)).
Prosite: PDOC00060;
PDB:
PDBScop
Cath: 3.20.20.10; 3.20.20.100; 3.40.50.720;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.197
BRENDA Enzyme Link: BRENDA 1.1.1.197
KEGG Enzyme Link: KEGG1.1.1.197
BioCyc Enzyme Link: BioCyc 1.1.1.197
ExPASy Enzyme Link: ExPASy1.1.1.197
EC2PDB Enzyme Link: EC2PDB 1.1.1.197
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.197
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.197
IntEnz Enzyme Link: IntEnz 1.1.1.197
MEDLINE Enzyme Link: MEDLINE 1.1.1.197

EC number:1.1.1.197

MSA:

1.1.1.197;
Phylogenetic Tree:

1.1.1.197;
Uniprot:
M-CSA:
RHEA:11636 NADP(+) + prostaglandin E1 = 15-oxo-prostaglandin E1 + H(+) + NADPH
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1
Reaction
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References

TitleAuthorsDatePubMed ID
Distribution of prostaglandin E 9-KETOREDUCTASE AND TYPES I and II 15-hydroxyprostaglandin dehydrogenase in swine kidney medulla and cortex.Lee SC, Pong SS, Katzen D, Wu KY, Levine L1975 Jan 14803247
Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types.Lee SC, Levine L1975 Jan 25234431