EC number:1.1.1.210
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.210 |
|---|---|
| Description: | 3-beta-(or 20-alpha)-hydroxysteroid dehydrogenase. |
| Alternative Name: |
Progesterone reductase. 3-beta-HSD. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.210 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.210 |
| KEGG Enzyme Link: | KEGG1.1.1.210 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.210 |
| ExPASy Enzyme Link: | ExPASy1.1.1.210 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.210 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.210 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.210 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.210 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.210 |
EC number:1.1.1.210
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:16297 | 5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism. | Jin Y, Duan L, Lee SH, Kloosterboer HJ, Blair IA, Penning TM | 2009 Apr 10 | 19218247 |
| Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action. | Steckelbroeck S, Jin Y, Gopishetty S, Oyesanmi B, Penning TM | 2004 Mar 12 | 14672942 |
| Sex hormone metabolism in prostate cancer cells during transition to an androgen-independent state. | Härkönen P, Törn S, Kurkela R, Porvari K, Pulkka A, Lindfors A, Isomaa V, Vihko P | 2003 Feb | 12574203 |