EC number:1.1.1.220

Enzyme

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     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.220
Description:6-pyruvoyltetrahydropterin 2'-reductase.
Alternative Name: Pyruvoyl-tetrahydropterin reductase.
6PPH4(2'-oxo) reductase.
6-pyruvoyl-tetrahydropterin 2'-reductase.
6-pyruvoyl tetrahydropterin (2'-oxo)reductase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.220
BRENDA Enzyme Link: BRENDA 1.1.1.220
KEGG Enzyme Link: KEGG1.1.1.220
BioCyc Enzyme Link: BioCyc 1.1.1.220
ExPASy Enzyme Link: ExPASy1.1.1.220
EC2PDB Enzyme Link: EC2PDB 1.1.1.220
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.220
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.220
IntEnz Enzyme Link: IntEnz 1.1.1.220
MEDLINE Enzyme Link: MEDLINE 1.1.1.220

EC number:1.1.1.220

MSA:

1.1.1.220;
Phylogenetic Tree:

1.1.1.220;
Uniprot:
M-CSA:
RHEA:11772 6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1
Reaction
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References

TitleAuthorsDatePubMed ID
Biosynthesis of tetrahydrobiopterin: conversion of dihydroneopterin triphosphate to tetrahydropterin intermediates.Milstien S, Kaufman S1985 May 164004850