EC number:1.1.1.236

Enzyme

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EC Tree
     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.236
Description:Tropinone reductase II.
Alternative Name: Tropinone reductase.
TR-II.
Pseudotropine forming tropinone reductase.
Prosite: PDOC00060;
PDB:
PDBScop
Cath: 3.40.50.720;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.236
BRENDA Enzyme Link: BRENDA 1.1.1.236
KEGG Enzyme Link: KEGG1.1.1.236
BioCyc Enzyme Link: BioCyc 1.1.1.236
ExPASy Enzyme Link: ExPASy1.1.1.236
EC2PDB Enzyme Link: EC2PDB 1.1.1.236
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.236
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.236
IntEnz Enzyme Link: IntEnz 1.1.1.236
MEDLINE Enzyme Link: MEDLINE 1.1.1.236

EC number:1.1.1.236

MSA:

1.1.1.236;
Phylogenetic Tree:

1.1.1.236;
Uniprot:
M-CSA:
RHEA:24244 NADP(+) + pseudotropine = H(+) + NADPH + tropinone
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1
Reaction
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References

TitleAuthorsDatePubMed ID
Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor.Nakajima K, Hashimoto T, Yamada Y1993 Oct 158415746
The functional divergence of short-chain dehydrogenases involved in tropinone reduction.Brock A, Brandt W, Dräger B2008 May18221363
Tropinone reductases, enzymes at the branch point of tropane alkaloid metabolism.Dräger B2006 Feb16426652