Enzyme

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     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.239
Description:3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)).
Alternative Name: 17-ketoreductase.
17-beta-HSD.
Cath: 3.20.20.10; 3.20.20.100; 3.40.50.720;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.239
BRENDA Enzyme Link: BRENDA 1.1.1.239
KEGG Enzyme Link: KEGG1.1.1.239
BioCyc Enzyme Link: BioCyc 1.1.1.239
ExPASy Enzyme Link: ExPASy1.1.1.239
EC2PDB Enzyme Link: EC2PDB 1.1.1.239
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.239
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.239
IntEnz Enzyme Link: IntEnz 1.1.1.239
MEDLINE Enzyme Link: MEDLINE 1.1.1.239
MSA:

1.1.1.239;

Phylogenetic Tree:

1.1.1.239;

Uniprot:
M-CSA:
RHEA:14929 NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1
Reaction
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References

TitleAuthorsDatePubMed ID
Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity.Wu L, Einstein M, Geissler WM, Chan HK, Elliston KO, Andersson S1993 Jun 158099587
Biochemical Mechanisms and Catabolic Enzymes Involved in Bacterial Estrogen Degradation Pathways.Chen YL, Yu CP, Lee TH, Goh KS, Chu KH, Wang PH, Ismail W, Shih CJ, Chiang YR2017 Jun 2228552583
Demonstration of 3 alpha(17 beta)-hydroxysteroid dehydrogenase distinct from 3 alpha-hydroxysteroid dehydrogenase in hamster liver.Ohmura M, Hara A, Nakagawa M, Sawada H1990 Mar 12317205
Expression in E. coli and tissue distribution of the human homologue of the mouse Ke 6 gene, 17beta-hydroxysteroid dehydrogenase type 8.Ohno S, Nishikawa K, Honda Y, Nakajin S2008 Feb17978863
Expanded substrate screenings of human and Drosophila type 10 17beta-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: characterization of multifunctional 3alpha/7alpha/7beta/17beta/20beta/21-HSD.Shafqat N, Marschall HU, Filling C, Nordling E, Wu XQ, Björk L, Thyberg J, Mårtensson E, Salim S, Jörnvall H, Oppermann U2003 Nov 1512917011
Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones.Penning TM, Burczynski ME, Jez JM, Hung CF, Lin HK, Ma H, Moore M, Palackal N, Ratnam K2000 Oct 110998348