EC number:1.1.1.252
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.252 | ||
|---|---|---|---|
| Description: | Tetrahydroxynaphthalene reductase. | ||
| Alternative Name: |
T4HN reductase. | ||
| Prosite: | PDOC00060; | ||
| PDB: |
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| Cath: | 3.10.450.50; 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.252 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.252 |
| KEGG Enzyme Link: | KEGG1.1.1.252 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.252 |
| ExPASy Enzyme Link: | ExPASy1.1.1.252 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.252 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.252 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.252 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.252 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.252 |
EC number:1.1.1.252
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:21908 | NADP(+) + scytalone = H(+) + NADPH + naphthalene-1,3,6,8-tetrol |
| RULE(radius=1) | [*:1]-[CH;+0:2]1-[CH2;+0:3]-[*:4]:[*:5]-[C;H0;+0:6](=[O;H0;+0:7])-[CH2;+0:8]-1.[*:9]-[n+;H0:10]1:[cH;+0:11]:[cH;+0:12]:[cH;+0:13]:[c;H0;+0:14](-[*:15]):[cH;+0:16]:1>>[*:9]-[N;H0;+0:10]1-[CH;+0:11]=[CH;+0:12]-[CH2;+0:13]-[C;H0;+0:14](-[*:15])=[CH;+0:16]-1.[*:1]-[c;H0;+0:2]1:[cH;+0:3]:[*:4]:[*:5]:[c;H0;+0:6](-[OH;+0:7]):[cH;+0:8]:1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Trihydroxynaphthalene reductase from Magnaporthe grisea: realization of an active center inhibitor and elucidation of the kinetic mechanism. | Thompson JE, Basarab GS, Andersson A, Lindqvist Y, Jordan DB | 1997 Feb 18 | 9048570 |
| Towards the first inhibitors of trihydroxynaphthalene reductase from Curvularia lunata: synthesis of artificial substrate, homology modelling and initial screening. | Brunskole M, Stefane B, Zorko K, Anderluh M, Stojan J, Lanisnik Rizner T, Gobec S | 2008 Jun 1 | 18482840 |
| Structures of trihydroxynaphthalene reductase-fungicide complexes: implications for structure-based design and catalysis. | Liao D, Basarab GS, Gatenby AA, Valent B, Jordan DB | 2001 Jan 10 | 11342131 |