EC number:1.1.1.262
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.262 |
|---|---|
| Description: | 4-hydroxythreonine-4-phosphate dehydrogenase. |
| Alternative Name: |
NAD(+)-dependent threonine 4-phosphate dehydrogenase. L-threonine 4-phosphate dehydrogenase. 4-(phosphohydroxy)-L-threonine dehydrogenase. |
| Cath: | 3.20.20.70; 3.30.360.10; 3.40.50.720; 3.40.50.880; 3.40.640.10; 3.40.718.10; 3.90.1150.10; 2.30.110.10; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.262 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.262 |
| KEGG Enzyme Link: | KEGG1.1.1.262 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.262 |
| ExPASy Enzyme Link: | ExPASy1.1.1.262 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.262 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.262 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.262 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.262 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.262 |
EC number:1.1.1.262
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:32275 | 4-(phosphooxy)-L-threonine + NAD(+) = 3-amino-2-oxopropyl phosphate + CO2 + NADH |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[C;H0;+0:10](-[OH;+0:11])-[CH;+0:12](-[*:13])-[CH;+0:14](-[*:15])-[OH;+0:16]>>[*:13]-[CH2;+0:12]-[C;H0;+0:14](-[*:15])=[O;H0;+0:16].[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[C;H0;+0:10]=[O;H0;+0:11] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystal structure of Escherichia coli PdxA, an enzyme involved in the pyridoxal phosphate biosynthesis pathway. | Sivaraman J, Li Y, Banks J, Cane DE, Matte A, Cygler M | 2003 Oct 31 | 12896974 |
| Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein. | Laber B, Maurer W, Scharf S, Stepusin K, Schmidt FS | 1999 Apr 16 | 10225425 |
| Biosynthesis of vitamin B6: direct identification of the product of the PdxA-catalyzed oxidation of 4-hydroxy-l-threonine-4-phosphate using electrospray ionization mass spectrometry. | Banks J, Cane DE | 2004 Apr 5 | 15026039 |