EC number:1.1.1.270
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.270 |
|---|---|
| Description: | 3-beta-hydroxysteroid 3-dehydrogenase. |
| Alternative Name: |
3-KSR. 3-keto-steroid reductase. |
| Cath: | 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.270 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.270 |
| KEGG Enzyme Link: | KEGG1.1.1.270 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.270 |
| ExPASy Enzyme Link: | ExPASy1.1.1.270 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.270 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.270 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.270 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.270 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.270 |
EC number:1.1.1.270
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:18409 | 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Solubilization and partial purification of a microsomal 3-ketosteroid reductase of cholesterol biosynthesis. | Billheimer JT, Alcorn M, Gaylor JL | 1981 Oct 1 | 6946726 |
| Investigation of the component reactions of oxidative sterol demethylation. Formation and metabolism of 3-ketosteroid intermediates. | Swindell AC, Gaylor JL | 1968 Nov 10 | 4387005 |
| Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis. | Marijanovic Z, Laubner D, Moller G, Gege C, Husen B, Adamski J, Breitling R | 2003 Sep | 12829805 |
| Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation. | Gachotte D, Sen SE, Eckstein J, Barbuch R, Krieger M, Ray BD, Bard M | 1999 Oct 26 | 10535978 |
| RHEA:34787 | a 3beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis. | Marijanovic Z, Laubner D, Moller G, Gege C, Husen B, Adamski J, Breitling R | 2003 Sep | 12829805 |
| Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation. | Gachotte D, Sen SE, Eckstein J, Barbuch R, Krieger M, Ray BD, Bard M | 1999 Oct 26 | 10535978 |
| RHEA:36379 | 4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + H(+) + NADPH = 4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[C;H0;+0:8](-[*:9])-[CH2;+0:10]-[CH;+0:11]=[CH;+0:12]-1.[H+;H0:13]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[c;H0;+0:8](-[*:9]):[cH;+0:10]:[cH;+0:11]:[cH;+0:12]:1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway. | Mazein A, Watterson S, Hsieh WY, Griffiths WJ, Ghazal P | 2013 Jul 1 | 23583456 |
| Divergent interactions involving the oxidosqualene cyclase and the steroid-3-ketoreductase in the sterol biosynthetic pathway of mammals and yeasts. | Taramino S, Teske B, Oliaro-Bosso S, Bard M, Balliano G | 2010 Nov | 20659585 |