EC number:1.1.1.271
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.271 |
|---|---|
| Description: | GDP-L-fucose synthase. |
| Alternative Name: |
GDP-fucose synthetase. GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase. |
| Cath: | 3.40.50.720; 3.90.25.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.271 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.271 |
| KEGG Enzyme Link: | KEGG1.1.1.271 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.271 |
| ExPASy Enzyme Link: | ExPASy1.1.1.271 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.271 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.271 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.271 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.271 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.271 |
EC number:1.1.1.271
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:18885 | GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| GDP-fucose synthetase from Escherichia coli: structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site. | Somers WS, Stahl ML, Sullivan FX | 1998 Dec 15 | 9862812 |
| Identification of the fucose synthetase gene in the colanic acid gene cluster of Escherichia coli K-12. | Andrianopoulos K, Wang L, Reeves PR | 1998 Feb | 9473059 |
| An epimerase-reductase in L-fucose synthesis. | Chang S, Duerr B, Serif G | 1988 Feb 5 | 3338988 |
| Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster. | Rhomberg S, Fuchsluger C, Rendić D, Paschinger K, Jantsch V, Kosma P, Wilson IB | 2006 May | 16650000 |
| Functional expression of Escherichia coli enzymes synthesizing GDP-L-fucose from inherent GDP-D-mannose in Saccharomyces cerevisiae. | Mattila P, Räbinä J, Hortling S, Helin J, Renkonen R | 2000 Oct | 11030750 |
| Probing the catalytic mechanism of GDP-4-keto-6-deoxy-d-mannose Epimerase/Reductase by kinetic and crystallographic characterization of site-specific mutants. | Rosano C, Bisso A, Izzo G, Tonetti M, Sturla L, De Flora A, Bolognesi M | 2000 Oct 13 | 11021971 |
| A bifunctional epimerase-reductase acts downstream of the MUR1 gene product and completes the de novo synthesis of GDP-L-fucose in Arabidopsis. | Bonin CP, Reiter WD | 2000 Mar | 10758496 |
| Stereochemical course and steady state mechanism of the reaction catalyzed by the GDP-fucose synthetase from Escherichia coli. | Menon S, Stahl M, Kumar R, Xu GY, Sullivan F | 1999 Sep 17 | 10480878 |