EC number:1.1.1.286
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.286 | ||
|---|---|---|---|
| Description: | Isocitrate--homoisocitrate dehydrogenase. | ||
| Alternative Name: |
Homoisocitrate--isocitrate dehydrogenase. | ||
| Prosite: | PDOC00389; | ||
| PDB: |
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3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.286 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.286 |
| KEGG Enzyme Link: | KEGG1.1.1.286 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.286 |
| ExPASy Enzyme Link: | ExPASy1.1.1.286 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.286 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.286 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.286 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.286 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.286 |
EC number:1.1.1.286
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:23632 | D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[C;H0;+0:3](=[*:4])-[OH;+0:5])-[CH;+0:6](-[*:7])-[OH;+0:8].[*:9]-[n+;H0:10]1:[cH;+0:11]:[cH;+0:12]:[cH;+0:13]:[c;H0;+0:14](-[*:15]):[cH;+0:16]:1>>[*:1]-[CH2;+0:2]-[C;H0;+0:6](-[*:7])=[O;H0;+0:8].[*:9]-[N;H0;+0:10]1-[CH;+0:11]=[CH;+0:12]-[CH2;+0:13]-[C;H0;+0:14](-[*:15])=[CH;+0:16]-1.[*:4]=[C;H0;+0:3]=[O;H0;+0:5] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase. | Miyazaki K | 2005 May 27 | 15845397 |
| Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. | Soundar S, Park JH, Huh TL, Colman RF | 2003 Dec 26 | 14555658 |
| RHEA:11900 | (1R,2S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[C;H0;+0:3](=[*:4])-[OH;+0:5])-[CH;+0:6](-[*:7])-[OH;+0:8].[*:9]-[n+;H0:10]1:[cH;+0:11]:[cH;+0:12]:[cH;+0:13]:[c;H0;+0:14](-[*:15]):[cH;+0:16]:1>>[*:1]-[CH2;+0:2]-[C;H0;+0:6](-[*:7])=[O;H0;+0:8].[*:9]-[N;H0;+0:10]1-[CH;+0:11]=[CH;+0:12]-[CH2;+0:13]-[C;H0;+0:14](-[*:15])=[CH;+0:16]-1.[*:4]=[C;H0;+0:3]=[O;H0;+0:5] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase. | Miyazaki K | 2005 May 27 | 15845397 |
| Lysine biosynthesis and metabolism in fungi. | Zabriskie TM, Jackson MD | 2000 Feb | 10714900 |