EC number:1.1.1.290
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.290 | ||
|---|---|---|---|
| Description: | 4-phosphoerythronate dehydrogenase. | ||
| Alternative Name: |
Erythronate-4-phosphate dehydrogenase. 4PE dehydrogenase. 4-O-phosphoerythronate dehydrogenase. | ||
| Prosite: | PDOC00063; | ||
| PDB: |
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| Cath: | 3.20.20.70; 3.30.1370.170; 3.30.360.10; 3.40.50.720; 3.40.50.880; 3.40.640.10; 3.90.1150.10; 2.30.110.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.290 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.290 |
| KEGG Enzyme Link: | KEGG1.1.1.290 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.290 |
| ExPASy Enzyme Link: | ExPASy1.1.1.290 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.290 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.290 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.290 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.290 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.290 |
EC number:1.1.1.290
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:18829 | 4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A new family of 2-hydroxyacid dehydrogenases. | Grant GA | 1989 Dec 29 | 2692566 |
| Divergent transcription of pdxB and homology between the pdxB and serA gene products in Escherichia coli K-12. | Schoenlein PV, Roa BB, Winkler ME | 1989 Nov | 2681152 |
| Metabolic relationships between pyridoxine (vitamin B6) and serine biosynthesis in Escherichia coli K-12. | Lam HM, Winkler ME | 1990 Nov | 2121717 |
| Positive growth rate-dependent regulation of the pdxA, ksgA, and pdxB genes of Escherichia coli K-12. | Pease AJ, Roa BR, Luo W, Winkler ME | 2002 Mar | 11844765 |
| A novel alpha-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria. | Zhao G, Winkler ME | 1996 Jan | 8550422 |