EC number:1.1.1.291
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.291 | ||
|---|---|---|---|
| Description: | 2-hydroxymethylglutarate dehydrogenase. | ||
| Prosite: | PDOC00697; | ||
| PDB: |
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| Cath: | 1.10.1040.10; 1.10.150.120; 3.20.20.140; 3.30.365.10; 3.30.390.50; 3.30.465.10; 3.40.50.720; 2.30.40.10; 3.40.50.12340; 3.10.20.30; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.291 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.291 |
| KEGG Enzyme Link: | KEGG1.1.1.291 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.291 |
| ExPASy Enzyme Link: | ExPASy1.1.1.291 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.291 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.291 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.291 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.291 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.291 |
EC number:1.1.1.291
| MSA: | |
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| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:15505 | 2-(hydroxymethyl)glutarate + NAD(+) = 2-formylglutarate + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[OH;+0:3].[*:4]-[n+;H0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:1>>[*:1]-[CH;+0:2]=[O;H0;+0:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-[C;H0;+0:9](-[*:10])=[CH;+0:11]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural and kinetic properties of a beta-hydroxyacid dehydrogenase involved in nicotinate fermentation. | Reitz S, Alhapel A, Essen LO, Pierik AJ | 2008 Oct 10 | 18680749 |
| Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri. | Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ | 2006 Aug 15 | 16894175 |