EC number:1.1.1.299
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.299 |
|---|---|
| Description: | Malate dehydrogenase (NAD(P)(+)). |
| Cath: | 3.40.50.720; 3.90.110.10; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.299 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.299 |
| KEGG Enzyme Link: | KEGG1.1.1.299 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.299 |
| ExPASy Enzyme Link: | ExPASy1.1.1.299 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.299 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.299 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.299 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.299 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.299 |
EC number:1.1.1.299
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:21432 | (S)-malate + NAD(+) = H(+) + NADH + oxaloacetate |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Two malate dehydrogenases in Methanobacterium thermoautotrophicum. | Thompson H, Tersteegen A, Thauer RK, Hedderich R | 1998 Jul | 9639601 |
| Beef heart malic dehydrogenases. VII. Reactivity of sulfhydryl groups and conformation of the supernatant enzyme. | Guha A, Englard S, Listowsky I | 1968 Feb 10 | 5637713 |
| Purification and properties of Drosophila malate dehydrogenases. | McReynolds MS, Kitto GB | 1970 Feb 11 | 4313528 |
| Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate. | Fan J, Teng X, Liu L, Mattaini KR, Looper RE, Vander Heiden MG, Rabinowitz JD | 2015 Feb 20 | 25406093 |
| Refolding, characterization and crystal structure of (S)-malate dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix. | Kawakami R, Sakuraba H, Goda S, Tsuge H, Ohshima T | 2009 Oct | 19555779 |
| Some molecular and kinetic properties of heart malic dehydrogenase. | WOLFE RG, NEILANDS JB | 1956 Jul | 13345798 |
| RHEA:10824 | (S)-malate + NADP(+) = H(+) + NADPH + oxaloacetate |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Two malate dehydrogenases in Methanobacterium thermoautotrophicum. | Thompson H, Tersteegen A, Thauer RK, Hedderich R | 1998 Jul | 9639601 |
| Beef heart malic dehydrogenases. VII. Reactivity of sulfhydryl groups and conformation of the supernatant enzyme. | Guha A, Englard S, Listowsky I | 1968 Feb 10 | 5637713 |
| Purification and properties of Drosophila malate dehydrogenases. | McReynolds MS, Kitto GB | 1970 Feb 11 | 4313528 |
| Refolding, characterization and crystal structure of (S)-malate dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix. | Kawakami R, Sakuraba H, Goda S, Tsuge H, Ohshima T | 2009 Oct | 19555779 |
| Some molecular and kinetic properties of heart malic dehydrogenase. | WOLFE RG, NEILANDS JB | 1956 Jul | 13345798 |
| NADP-malate dehydrogenase from Chlamydomonas: prediction of new structural determinants for redox regulation by homology modelling. | Gómez Ia, Merchán F, Fernández E, Quesada A | 2002 Feb 1 | 11855723 |