EC number:1.1.1.300

Enzyme

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     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.300
Description:NADP-retinol dehydrogenase.
Alternative Name: Retinol dehydrogenase (NADP(+)).
NADP(H)-dependent retinol dehydrogenase/reductase.
All-trans-retinol dehydrogenase.
All-trans retinal reductase.
Prosite: PDOC00060;
PDB:
PDBScop

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.300
BRENDA Enzyme Link: BRENDA 1.1.1.300
KEGG Enzyme Link: KEGG1.1.1.300
BioCyc Enzyme Link: BioCyc 1.1.1.300
ExPASy Enzyme Link: ExPASy1.1.1.300
EC2PDB Enzyme Link: EC2PDB 1.1.1.300
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.300
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.300
IntEnz Enzyme Link: IntEnz 1.1.1.300
MEDLINE Enzyme Link: MEDLINE 1.1.1.300

EC number:1.1.1.300

MSA:

1.1.1.300;
Phylogenetic Tree:

1.1.1.300;
Uniprot:
M-CSA:
RHEA:25033 all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH
RULE(radius=1) [*:1]-[CH2;+0:2]-[OH;+0:3].[*:4]-[n+;H0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:1>>[*:1]-[CH;+0:2]=[O;H0;+0:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-[C;H0;+0:9](-[*:10])=[CH;+0:11]-1
Reaction
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References

TitleAuthorsDatePubMed ID
Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal.Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K1998 Aug 219705317
Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15: A Novel Human Retinaldehyde Reductase.Giménez-Dejoz J, Kolář MH, Ruiz FX, Crespo I, Cousido-Siah A, Podjarny A, Barski OA, Fanfrlík J, Parés X, Farrés J, Porté S201526222439
Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity.Belyaeva OV, Korkina OV, Stetsenko AV, Kedishvili NY2008 Jan18039331
Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids.Gallego O, Belyaeva OV, Porté S, Ruiz FX, Stetsenko AV, Shabrova EV, Kostereva NV, Farrés J, Parés X, Kedishvili NY2006 Oct 116787387
Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids.Belyaeva OV, Korkina OV, Stetsenko AV, Kim T, Nelson PS, Kedishvili NY2005 May 1015865448
Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism.Crosas B, Hyndman DJ, Gallego O, Martras S, Parés X, Flynn TG, Farrés J2003 Aug 112732097
Human pancreas protein 2 (PAN2) has a retinal reductase activity and is ubiquitously expressed in human tissues.Belyaeva OV, Kedishvili NY2002 Nov 2012435598
Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE.Wu BX, Chen Y, Chen Y, Fan J, Rohrer B, Crouch RK, Ma JX2002 Nov12407145
Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina.Haeseleer F, Jang GF, Imanishi Y, Driessen CAGG, Matsumura M, Nelson PS, Palczewski K2002 Nov 2212226107
Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1).Kedishvili NY, Chumakova OV, Chetyrkin SV, Belyaeva OV, Lapshina EA, Lin DW, Matsumura M, Nelson PS2002 Aug 912036956