EC number:1.1.1.305
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.305 |
|---|---|
| Description: | UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating). |
| Alternative Name: |
UDP-GlcUA decarboxylase. ArnADH. |
| Cath: | 3.40.50.720; 3.90.25.10; 3.40.50.12230; 3.40.50.170; 3.10.25.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.305 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.305 |
| KEGG Enzyme Link: | KEGG1.1.1.305 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.305 |
| ExPASy Enzyme Link: | ExPASy1.1.1.305 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.305 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.305 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.305 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.305 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.305 |
EC number:1.1.1.305
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:24702 | NAD(+) + UDP-alpha-D-glucuronate = CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[C;H0;+0:10](-[OH;+0:11])-[CH;+0:12](-[*:13])-[CH;+0:14](-[*:15])-[OH;+0:16]>>[*:13]-[CH2;+0:12]-[C;H0;+0:14](-[*:15])=[O;H0;+0:16].[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[C;H0;+0:10]=[O;H0;+0:11] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis. | Williams GJ, Breazeale SD, Raetz CR, Naismith JH | 2005 Jun 17 | 15809294 |
| Crystal structure of Escherichia coli ArnA (PmrI) decarboxylase domain. A key enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance. | Gatzeva-Topalova PZ, May AP, Sousa MC | 2004 Oct 26 | 15491143 |
| Oxidative decarboxylation of UDP-glucuronic acid in extracts of polymyxin-resistant Escherichia coli. Origin of lipid a species modified with 4-amino-4-deoxy-L-arabinose. | Breazeale SD, Ribeiro AA, Raetz CR | 2002 Jan 25 | 11706007 |