EC number:1.1.1.315
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.315 |
|---|---|
| Description: | 11-cis-retinol dehydrogenase. |
| Cath: | 3.40.50.720; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.315 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.315 |
| KEGG Enzyme Link: | KEGG1.1.1.315 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.315 |
| ExPASy Enzyme Link: | ExPASy1.1.1.315 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.315 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.315 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.315 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.315 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.315 |
EC number:1.1.1.315
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:55668 | 11-cis-retinol--[retinol-binding protein] + NAD(+) = 11-cis-retinal--[retinol-binding protein] + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[OH;+0:3].[*:4]-[n+;H0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:1>>[*:1]-[CH;+0:2]=[O;H0;+0:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-[C;H0;+0:9](-[*:10])=[CH;+0:11]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mapping the ligand binding pocket in the cellular retinaldehyde binding protein. | Wu Z, Yang Y, Shaw N, Bhattacharya S, Yan L, West K, Roth K, Noy N, Qin J, Crabb JW | 2003 Apr 4 | 12536149 |
| The visual cycle retinol dehydrogenase: possible involvement in the 9-cis retinoic acid biosynthetic pathway. | Driessen CA, Winkens HJ, Kuhlmann ED, Janssen AP, van Vugt AH, Deutman AF, Janssen JJ | 1998 May 29 | 9654122 |
| The identification of a 9-cis retinol dehydrogenase in the mouse embryo reveals a pathway for synthesis of 9-cis retinoic acid. | Romert A, Tuvendal P, Simon A, Dencker L, Eriksson U | 1998 Apr 14 | 9539749 |
| Identification and characterization of a stereospecific human enzyme that catalyzes 9-cis-retinol oxidation. A possible role in 9-cis-retinoic acid formation. | Mertz JR, Shang E, Piantedosi R, Wei S, Wolgemuth DJ, Blaner WS | 1997 May 2 | 9115228 |
| The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases. | Simon A, Hellman U, Wernstedt C, Eriksson U | 1995 Jan 20 | 7836368 |
| Cloning and expression of a cDNA encoding bovine retinal pigment epithelial 11-cis retinol dehydrogenase. | Driessen CA, Janssen BP, Winkens HJ, van Vugt AH, de Leeuw TL, Janssen JJ | 1995 Sep | 7544779 |
| Biochemical properties, tissue expression, and gene structure of a short chain dehydrogenase/ reductase able to catalyze cis-retinol oxidation. | Gamble MV, Shang E, Zott RP, Mertz JR, Wolgemuth DJ, Blaner WS | 1999 Dec | 10588954 |
| RHEA:42060 | 11-cis-retinol + NAD(+) = 11-cis-retinal + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[OH;+0:3].[*:4]-[n+;H0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:1>>[*:1]-[CH;+0:2]=[O;H0;+0:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-[C;H0;+0:9](-[*:10])=[CH;+0:11]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| cDNA cloning and characterization of a cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase. | Chai X, Zhai Y, Napoli JL | 1997 Dec 26 | 9407098 |
| Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue. | Wang J, Chai X, Eriksson U, Napoli JL | 1999 Feb 15 | 9931293 |
| The visual cycle retinol dehydrogenase: possible involvement in the 9-cis retinoic acid biosynthetic pathway. | Driessen CA, Winkens HJ, Kuhlmann ED, Janssen AP, van Vugt AH, Deutman AF, Janssen JJ | 1998 May 29 | 9654122 |
| The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases. | Simon A, Hellman U, Wernstedt C, Eriksson U | 1995 Jan 20 | 7836368 |
| Cloning and expression of a cDNA encoding bovine retinal pigment epithelial 11-cis retinol dehydrogenase. | Driessen CA, Janssen BP, Winkens HJ, van Vugt AH, de Leeuw TL, Janssen JJ | 1995 Sep | 7544779 |
| Biochemical properties, tissue expression, and gene structure of a short chain dehydrogenase/ reductase able to catalyze cis-retinol oxidation. | Gamble MV, Shang E, Zott RP, Mertz JR, Wolgemuth DJ, Blaner WS | 1999 Dec | 10588954 |
| Mutations in the gene encoding 11-cis retinol dehydrogenase cause delayed dark adaptation and fundus albipunctatus. | Yamamoto H, Simon A, Eriksson U, Harris E, Berson EL, Dryja TP | 1999 Jun | 10369264 |