EC number:1.1.1.325
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.325 |
|---|---|
| Description: | Sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming). |
| Cath: | 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.325 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.325 |
| KEGG Enzyme Link: | KEGG1.1.1.325 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.325 |
| ExPASy Enzyme Link: | ExPASy1.1.1.325 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.325 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.325 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.325 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.325 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.325 |
EC number:1.1.1.325
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:32623 | L-threo-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH |
| RULE(radius=1) | ([*:1]-[CH;+0:2](-[OH;+0:3])-[CH;+0:4](-[*:5])-[OH;+0:6].[*:7]:[nH;+0:8]:[*:9]:[n;H0;+0:10]:[*:11]).[*:12]-[c;H0;+0:13]1:[cH;+0:14]:[cH;+0:15]:[cH;+0:16]:[n+;H0:17](-[*:18]):[cH;+0:19]:1.[*:20]-[n+;H0:21]1:[cH;+0:22]:[cH;+0:23]:[cH;+0:24]:[c;H0;+0:25](-[*:26]):[cH;+0:27]:1>>([*:1]-[C;H0;+0:2](=[O;H0;+0:3])-[C;H0;+0:4](-[*:5])=[O;H0;+0:6].[*:7]:[n;H0;+0:8]:[*:9]:[nH;+0:10]:[*:11]).[*:12]-[C;H0;+0:13]1=[CH;+0:19]-[N;H0;+0:17](-[*:18])-[CH;+0:16]=[CH;+0:15]-[CH2;+0:14]-1.[*:20]-[N;H0;+0:21]1-[CH;+0:22]=[CH;+0:23]-[CH2;+0:24]-[C;H0;+0:25](-[*:26])=[CH;+0:27]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Expression, purification, crystallization and preliminary X-ray analysis of sepiapterin reductase from Chlorobium tepidum. | Supangat S, Choi YK, Park YS, Son D, Han CD, Lee KH | 2005 Feb 1 | 16510994 |
| Sepiapterin reductase producing L-threo-dihydrobiopterin from Chlorobium tepidum. | Cho SH, Na JU, Youn H, Hwang CS, Lee CH, Kang SO | 1999 Jun 1 | 10333495 |
| RHEA:32619 | L-threo-7,8-dihydrobiopterin + NADP(+) = H(+) + NADPH + sepiapterin |
| RULE(radius=1) | ([*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]:[n;H0;+0:6]:[*:7]:[nH;+0:8]:[*:9]).[*:10]-[n+;H0:11]1:[cH;+0:12]:[cH;+0:13]:[cH;+0:14]:[c;H0;+0:15](-[*:16]):[cH;+0:17]:1>>([*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]:[nH;+0:6]:[*:7]:[n;H0;+0:8]:[*:9]).[*:10]-[N;H0;+0:11]1-[CH;+0:12]=[CH;+0:13]-[CH2;+0:14]-[C;H0;+0:15](-[*:16])=[CH;+0:17]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Expression, purification, crystallization and preliminary X-ray analysis of sepiapterin reductase from Chlorobium tepidum. | Supangat S, Choi YK, Park YS, Son D, Han CD, Lee KH | 2005 Feb 1 | 16510994 |
| Sepiapterin reductase producing L-threo-dihydrobiopterin from Chlorobium tepidum. | Cho SH, Na JU, Youn H, Hwang CS, Lee CH, Kang SO | 1999 Jun 1 | 10333495 |