EC number:1.1.1.330
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.330 |
|---|---|
| Description: | Very-long-chain 3-oxoacyl-CoA reductase. |
| Alternative Name: |
Very-long-chain beta-ketoacyl-CoA reductase. Very-long-chain 3-ketoacyl-CoA reductase. |
| Cath: | 3.10.20.90; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.330 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.330 |
| KEGG Enzyme Link: | KEGG1.1.1.330 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.330 |
| ExPASy Enzyme Link: | ExPASy1.1.1.330 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.330 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.330 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.330 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.330 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.330 |
EC number:1.1.1.330
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:48680 | a very-long-chain (3R)-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[c;H0;+0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[n+;H0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[C;H0;+0:6]1=[CH;+0:12]-[N;H0;+0:10](-[*:11])-[CH;+0:9]=[CH;+0:8]-[CH2;+0:7]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| LET-767 is required for the production of branched chain and long chain fatty acids in Caenorhabditis elegans. | Entchev EV, Schwudke D, Zagoriy V, Matyash V, Bogdanova A, Habermann B, Zhu L, Shevchenko A, Kurzchalia TV | 2008 Jun 20 | 18390550 |
| Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade. | Moon YA, Horton JD | 2003 Feb 28 | 12482854 |
| The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase. | Han G, Gable K, Kohlwein SD, Beaudoin F, Napier JA, Dunn TM | 2002 Sep 20 | 12087109 |
| Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase. | Beaudoin F, Wu X, Li F, Haslam RP, Markham JE, Zheng H, Napier JA, Kunst L | 2009 Jul | 19439572 |
| A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase. | Beaudoin F, Gable K, Sayanova O, Dunn T, Napier JA | 2002 Mar 29 | 11792704 |