EC number:1.1.1.331
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.331 |
|---|---|
| Description: | Secoisolariciresinol dehydrogenase. |
| Cath: | 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.331 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.331 |
| KEGG Enzyme Link: | KEGG1.1.1.331 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.331 |
| ExPASy Enzyme Link: | ExPASy1.1.1.331 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.331 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.331 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.331 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.331 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.331 |
EC number:1.1.1.331
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:33887 | (-)-secoisolariciresinol + 2 NAD(+) = (-)-matairesinol + 2 H(+) + 2 NADH |
| RULE(radius=1) | ([*:1]-[CH2;+0:2]-[OH;+0:3].[*:4]-[OH;+0:5]).[*:6]-[c;H0;+0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[n+;H0:11](-[*:12]):[cH;+0:13]:1.[*:14]-[n+;H0:15]1:[cH;+0:16]:[cH;+0:17]:[cH;+0:18]:[c;H0;+0:19](-[*:20]):[cH;+0:21]:1>>[*:6]-[C;H0;+0:7]1=[CH;+0:13]-[N;H0;+0:11](-[*:12])-[CH;+0:10]=[CH;+0:9]-[CH2;+0:8]-1.[*:14]-[N;H0;+0:15]1-[CH;+0:16]=[CH;+0:17]-[CH2;+0:18]-[C;H0;+0:19](-[*:20])=[CH;+0:21]-1.[*:4]-[O;H0;+0:5]-[C;H0;+0:2](-[*:1])=[O;H0;+0:3] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum. | Moinuddin SG, Youn B, Bedgar DL, Costa MA, Helms GL, Kang C, Davin LB, Lewis NG | 2006 Mar 7 | 16493463 |
| Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans. | Youn B, Moinuddin SG, Davin LB, Lewis NG, Kang C | 2005 Apr 1 | 15653677 |
| Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection. | Xia ZQ, Costa MA, Pelissier HC, Davin LB, Lewis NG | 2001 Apr 20 | 11278426 |