EC number:1.1.1.345

Enzyme

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     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.345
Description:D-2-hydroxyacid dehydrogenase (NAD(+)).
Alternative Name: D-2-hydroxyisocaproate dehydrogenase.
(R)-2-hydroxyisocaproate dehydrogenase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.345
BRENDA Enzyme Link: BRENDA 1.1.1.345
KEGG Enzyme Link: KEGG1.1.1.345
BioCyc Enzyme Link: BioCyc 1.1.1.345
ExPASy Enzyme Link: ExPASy1.1.1.345
EC2PDB Enzyme Link: EC2PDB 1.1.1.345
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.345
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.345
IntEnz Enzyme Link: IntEnz 1.1.1.345
MEDLINE Enzyme Link: MEDLINE 1.1.1.345

EC number:1.1.1.345

MSA:

1.1.1.345;
Phylogenetic Tree:

1.1.1.345;
Uniprot:
M-CSA:
RHEA:35643 a (2R)-2-hydroxycarboxylate + NAD(+) = a 2-oxocarboxylate + H(+) + NADH
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
2-Hydroxyacid dehydrogenase from Haloferax mediterranei, a D-isomer-specific member of the 2-hydroxyacid dehydrogenase family.Bonete MJ, Ferrer J, Pire C, Penades M, Ruiz JL2000 Dec11120357
RHEA:10052 (R)-2-hydroxy-4-methylpentanoate + NAD(+) = 4-methyl-2-oxopentanoate + H(+) + NADH
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
2-Hydroxyacid dehydrogenase from Haloferax mediterranei, a D-isomer-specific member of the 2-hydroxyacid dehydrogenase family.Bonete MJ, Ferrer J, Pire C, Penades M, Ruiz JL2000 Dec11120357