EC number:1.1.1.348

Enzyme

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EC Tree
     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.348
Description:(3R)-2'-hydroxyisoflavanone reductase.
Alternative Name: Vestitone reductase.
Cath: 3.40.50.720;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.348
BRENDA Enzyme Link: BRENDA 1.1.1.348
KEGG Enzyme Link: KEGG1.1.1.348
BioCyc Enzyme Link: BioCyc 1.1.1.348
ExPASy Enzyme Link: ExPASy1.1.1.348
EC2PDB Enzyme Link: EC2PDB 1.1.1.348
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.348
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.348
IntEnz Enzyme Link: IntEnz 1.1.1.348
MEDLINE Enzyme Link: MEDLINE 1.1.1.348

EC number:1.1.1.348

MSA:

1.1.1.348;
Phylogenetic Tree:

1.1.1.348;
Uniprot:
M-CSA:
RHEA:35403 (3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+) = (3R)-vestitone + H(+) + NADPH
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1
Reaction
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References

TitleAuthorsDatePubMed ID
Conversion of vestitone to medicarpin in alfalfa (Medicago sativa L.) is catalyzed by two independent enzymes. Identification, purification, and characterization of vestitone reductase and 7,2'-dihydroxy-4'-methoxyisoflavanol dehydratase.Guo L, Dixon RA, Paiva NL1994 Sep 28071365
The 'pterocarpan synthase' of alfalfa: association and co-induction of vestitone reductase and 7,2'-dihydroxy-4'-methoxy-isoflavanol (DMI) dehydratase, the two final enzymes in medicarpin biosynthesis.Guo L, Dixon RA, Paiva NL1994 Dec 197805842
Molecular cloning and expression of alfalfa (Medicago sativa L.) vestitone reductase, the penultimate enzyme in medicarpin biosynthesis.Guo L, Paiva NL1995 Jul 107625843
Crystal structure of vestitone reductase from alfalfa (Medicago sativa L.).Shao H, Dixon RA, Wang X2007 May 2517433362