EC number:1.1.1.353
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.353 |
|---|---|
| Description: | Versiconal hemiacetal acetate reductase. |
| Alternative Name: |
VHA reductase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.353 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.353 |
| KEGG Enzyme Link: | KEGG1.1.1.353 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.353 |
| ExPASy Enzyme Link: | ExPASy1.1.1.353 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.353 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.353 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.353 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.353 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.353 |
EC number:1.1.1.353
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:35691 | (2S)-versicolorone + NADP(+) = 1'-hydroxyversicolorone + H(+) + NADPH |
| RULE(radius=1) | ([*:1]-[CH2;+0:2]-[*:3].[*:4]-[OH;+0:5]).[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1.[*:4]-[O;H0;+0:5]-[CH;+0:2](-[*:1])-[*:3] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Participation in aflatoxin biosynthesis by a reductase enzyme encoded by vrdA gene outside the aflatoxin gene cluster. | Shima Y, Shiina M, Shinozawa T, Ito Y, Nakajima H, Adachi Y, Yabe K | 2009 Mar | 19211038 |
| Purification and characterization of two versiconal hemiacetal acetate reductases involved in aflatoxin biosynthesis. | Matsushima K, Ando Y, Hamasaki T, Yabe K | 1994 Jul | 16349333 |
| RHEA:35695 | (3S)-versiconol acetate + NADP(+) = (2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH |
| RULE(radius=1) | ([*:1]-[CH2;+0:2]-[*:3].[*:4]-[OH;+0:5]).[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1.[*:4]-[O;H0;+0:5]-[CH;+0:2](-[*:1])-[*:3] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Participation in aflatoxin biosynthesis by a reductase enzyme encoded by vrdA gene outside the aflatoxin gene cluster. | Shima Y, Shiina M, Shinozawa T, Ito Y, Nakajima H, Adachi Y, Yabe K | 2009 Mar | 19211038 |
| Purification and characterization of two versiconal hemiacetal acetate reductases involved in aflatoxin biosynthesis. | Matsushima K, Ando Y, Hamasaki T, Yabe K | 1994 Jul | 16349333 |
| RHEA:35699 | (S)-versiconol + NADP(+) = (2S-3S)-versiconal hemiacetal + H(+) + NADPH |
| RULE(radius=1) | ([*:1]-[CH2;+0:2]-[*:3].[*:4]-[OH;+0:5]).[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1.[*:4]-[O;H0;+0:5]-[CH;+0:2](-[*:1])-[*:3] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Participation in aflatoxin biosynthesis by a reductase enzyme encoded by vrdA gene outside the aflatoxin gene cluster. | Shima Y, Shiina M, Shinozawa T, Ito Y, Nakajima H, Adachi Y, Yabe K | 2009 Mar | 19211038 |
| Purification and characterization of two versiconal hemiacetal acetate reductases involved in aflatoxin biosynthesis. | Matsushima K, Ando Y, Hamasaki T, Yabe K | 1994 Jul | 16349333 |