EC Tree |
1. Oxidoreductases |
1.1 Acting on the CH-OH group of donors |
1.1.1 With NAD+ or NADP+ as acceptor |
ID: | 1.1.1.359 |
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Description: | Aldose 1-dehydrogenase (NAD(P)(+)). |
Cath: | 3.40.50.720; 3.90.180.10; |
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.UniProtKB Enzyme Link: | UniProtKB 1.1.1.359 |
BRENDA Enzyme Link: | BRENDA 1.1.1.359 |
KEGG Enzyme Link: | KEGG1.1.1.359 |
BioCyc Enzyme Link: | BioCyc 1.1.1.359 |
ExPASy Enzyme Link: | ExPASy1.1.1.359 |
EC2PDB Enzyme Link: | EC2PDB 1.1.1.359 |
ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.359 |
PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.359 |
IntEnz Enzyme Link: | IntEnz 1.1.1.359 |
MEDLINE Enzyme Link: | MEDLINE 1.1.1.359 |
MSA: | |
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Phylogenetic Tree: | |
Uniprot: | |
M-CSA: |
RHEA:13861 | D-xylose + NAD(+) = D-xylono-1,5-lactone + H(+) + NADH |
RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
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Core-to-Core |
RHEA:14293 | D-glucose + NAD(+) = D-glucono-1,5-lactone + H(+) + NADH |
RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
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Title | Authors | Date | PubMed ID |
---|---|---|---|
Carbohydrate metabolism in Thermoproteus tenax: in vivo utilization of the non-phosphorylative Entner-Doudoroff pathway and characterization of its first enzyme, glucose dehydrogenase. | Siebers B, Wendisch VF, Hensel R | 1997 Aug | 9238103 |
Glucose dehydrogenase from the halophilic Archaeon Haloferax mediterranei: enzyme purification, characterisation and N-terminal sequence. | Bonete MJ, Pire C, LLorca FI, Camacho ML | 1996 Apr 1 | 8925901 |
Cloning, sequencing and expression of the gene encoding glucose dehydrogenase from the thermophilic archaeon Thermoplasma acidophilum. | Bright JR, Byrom D, Danson MJ, Hough DW, Towner P | 1993 Feb 1 | 8436115 |
Glucose dehydrogenase from the thermoacidophilic archaebacterium Sulfolobus solfataricus. | Giardina P, de Biasi MG, de Rosa M, Gambacorta A, Buonocore V | 1986 Nov 1 | 3827812 |
Purification and characterization of glucose dehydrogenase from the thermoacidophilic archaebacterium Thermoplasma acidophilum. | Smith LD, Budgen N, Bungard SJ, Danson MJ, Hough DW | 1989 Aug 1 | 2803257 |
Metabolic pathway promiscuity in the archaeon Sulfolobus solfataricus revealed by studies on glucose dehydrogenase and 2-keto-3-deoxygluconate aldolase. | Lamble HJ, Heyer NI, Bull SD, Hough DW, Danson MJ | 2003 Sep 5 | 12824170 |
Heterologous overexpression of glucose dehydrogenase from the halophilic archaeon Haloferax mediterranei, an enzyme of the medium chain dehydrogenase/reductase family. | Pire C, Esclapez J, Ferrer J, Bonete MJ | 2001 Jun 25 | 11425479 |
RHEA:14405 | D-glucose + NADP(+) = D-glucono-1,5-lactone + H(+) + NADPH |
RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
Reaction | ![]() |
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Core-to-Core |
Title | Authors | Date | PubMed ID |
---|---|---|---|
Carbohydrate metabolism in Thermoproteus tenax: in vivo utilization of the non-phosphorylative Entner-Doudoroff pathway and characterization of its first enzyme, glucose dehydrogenase. | Siebers B, Wendisch VF, Hensel R | 1997 Aug | 9238103 |
Glucose dehydrogenase from the halophilic Archaeon Haloferax mediterranei: enzyme purification, characterisation and N-terminal sequence. | Bonete MJ, Pire C, LLorca FI, Camacho ML | 1996 Apr 1 | 8925901 |
Cloning, sequencing and expression of the gene encoding glucose dehydrogenase from the thermophilic archaeon Thermoplasma acidophilum. | Bright JR, Byrom D, Danson MJ, Hough DW, Towner P | 1993 Feb 1 | 8436115 |
Glucose dehydrogenase from the thermoacidophilic archaebacterium Sulfolobus solfataricus. | Giardina P, de Biasi MG, de Rosa M, Gambacorta A, Buonocore V | 1986 Nov 1 | 3827812 |
Purification and characterization of glucose dehydrogenase from the thermoacidophilic archaebacterium Thermoplasma acidophilum. | Smith LD, Budgen N, Bungard SJ, Danson MJ, Hough DW | 1989 Aug 1 | 2803257 |
The structural basis of substrate promiscuity in glucose dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus. | Milburn CC, Lamble HJ, Theodossis A, Bull SD, Hough DW, Danson MJ, Taylor GL | 2006 May 26 | 16556607 |
Properties of the recombinant glucose/galactose dehydrogenase from the extreme thermoacidophile, Picrophilus torridus. | Angelov A, Fütterer O, Valerius O, Braus GH, Liebl W | 2005 Feb | 15691337 |
Metabolic pathway promiscuity in the archaeon Sulfolobus solfataricus revealed by studies on glucose dehydrogenase and 2-keto-3-deoxygluconate aldolase. | Lamble HJ, Heyer NI, Bull SD, Hough DW, Danson MJ | 2003 Sep 5 | 12824170 |
Heterologous overexpression of glucose dehydrogenase from the halophilic archaeon Haloferax mediterranei, an enzyme of the medium chain dehydrogenase/reductase family. | Pire C, Esclapez J, Ferrer J, Bonete MJ | 2001 Jun 25 | 11425479 |
RHEA:15917 | an aldopyranose + NAD(+) = aldono-1,5-lactone + H(+) + NADH |
RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
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Title | Authors | Date | PubMed ID |
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Antiviral therapy in AIDS. Clinical pharmacological properties and therapeutic experience to date. | Sandström EG, Kaplan JC | 1987 Sep | 2824170 |
An additional glucose dehydrogenase from Sulfolobus solfataricus: fine-tuning of sugar degradation? | Haferkamp P, Kutschki S, Treichel J, Hemeda H, Sewczyk K, Hoffmann D, Zaparty M, Siebers B | 2011 Jan | 21265750 |
Glucose dehydrogenase from the thermoacidophilic archaebacterium Sulfolobus solfataricus. | Giardina P, de Biasi MG, de Rosa M, Gambacorta A, Buonocore V | 1986 Nov 1 | 3827812 |
Purification and characterization of glucose dehydrogenase from the thermoacidophilic archaebacterium Thermoplasma acidophilum. | Smith LD, Budgen N, Bungard SJ, Danson MJ, Hough DW | 1989 Aug 1 | 2803257 |
RHEA:17925 | L-arabinofuranose + NAD(+) = H(+) + L-arabinono-1,4-lactone + NADH |
RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
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Title | Authors | Date | PubMed ID |
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L-Arabinose degradation pathway in the haloarchaeon Haloferax volcanii involves a novel type of L-arabinose dehydrogenase. | Johnsen U, Sutter JM, Zaiß H, Schönheit P | 2013 Nov | 23949136 |
Cloning, expression, and characterization of bacterial L-arabinose 1-dehydrogenase involved in an alternative pathway of L-arabinose metabolism. | Watanabe S, Kodaki T, Makino K | 2006 Feb 3 | 16326697 |
The oxidation of L-arabinose by Pseudomonas saccharophila. | WEIMBERG R, DOUDOROFF M | 1955 Dec | 13271422 |
RHEA:18625 | D-galactose + NADP(+) = D-galactono-1,5-lactone + H(+) + NADPH |
RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
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Title | Authors | Date | PubMed ID |
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Some physical properties of three sugar dehydrogenases from a pseudomonad. | Cline AL, Hu AS | 1965 Nov | 5845849 |
Enzymatic characterization and comparison of three sugar dehydrogenases from a pseudomonad. | Cline AL, Hu AS | 1965 Nov | 5845848 |
The isolation of three sugar dehydrogenases from a psuedomonad. | Cline AL, Hu AS | 1965 Nov | 5845847 |
[Degradation of deoxysurgars by bacterial enzymes. V. Purification and characterization of an NADP-dependent abequose dehydrogenase from Pseudomonas putida]. | Schiwara HW, Domagk GF | 1968 Oct | 4387016 |
RHEA:22000 | D-xylose + NADP(+) = D-xylono-1,5-lactone + H(+) + NADPH |
RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
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Title | Authors | Date | PubMed ID |
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Evidence of a plasmid-encoded oxidative xylose-catabolic pathway in Arthrobacter nicotinovorans pAO1. | Mihasan M, Stefan M, Hritcu L, Artenie V, Brandsch R | 2013 Jan | 23063486 |
D-xylose degradation pathway in the halophilic archaeon Haloferax volcanii. | Johnsen U, Dambeck M, Zaiss H, Fuhrer T, Soppa J, Sauer U, Schönheit P | 2009 Oct 2 | 19584053 |
RHEA:36587 | an aldopyranose + NADP(+) = aldono-1,5-lactone + H(+) + NADPH |
RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
Reaction | ![]() |
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Title | Authors | Date | PubMed ID |
---|---|---|---|
Glucose dehydrogenase from the thermoacidophilic archaebacterium Sulfolobus solfataricus. | Giardina P, de Biasi MG, de Rosa M, Gambacorta A, Buonocore V | 1986 Nov 1 | 3827812 |
The structural basis of substrate promiscuity in glucose dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus. | Milburn CC, Lamble HJ, Theodossis A, Bull SD, Hough DW, Danson MJ, Taylor GL | 2006 May 26 | 16556607 |
RHEA:42392 | D-galactose + NAD(+) = D-galactono-1,5-lactone + H(+) + NADH |
RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
Reaction | ![]() |
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Core-to-Core |
Title | Authors | Date | PubMed ID |
---|---|---|---|
Glucose dehydrogenase from the thermoacidophilic archaebacterium Sulfolobus solfataricus. | Giardina P, de Biasi MG, de Rosa M, Gambacorta A, Buonocore V | 1986 Nov 1 | 3827812 |
The structural basis of substrate promiscuity in glucose dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus. | Milburn CC, Lamble HJ, Theodossis A, Bull SD, Hough DW, Danson MJ, Taylor GL | 2006 May 26 | 16556607 |
Metabolic pathway promiscuity in the archaeon Sulfolobus solfataricus revealed by studies on glucose dehydrogenase and 2-keto-3-deoxygluconate aldolase. | Lamble HJ, Heyer NI, Bull SD, Hough DW, Danson MJ | 2003 Sep 5 | 12824170 |