Enzyme

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     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.363
Description:Glucose-6-phosphate dehydrogenase (NAD(P)(+)).
Alternative Name: Glc6PD.
G6PDH.
G6PD.
Cath: 3.30.360.10; 3.40.50.720; 3.40.50.1360;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.363
BRENDA Enzyme Link: BRENDA 1.1.1.363
KEGG Enzyme Link: KEGG1.1.1.363
BioCyc Enzyme Link: BioCyc 1.1.1.363
ExPASy Enzyme Link: ExPASy1.1.1.363
EC2PDB Enzyme Link: EC2PDB 1.1.1.363
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.363
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.363
IntEnz Enzyme Link: IntEnz 1.1.1.363
MEDLINE Enzyme Link: MEDLINE 1.1.1.363
MSA:

1.1.1.363;

Phylogenetic Tree:

1.1.1.363;

Uniprot:
M-CSA:
RHEA:38215 D-glucose 6-phosphate + NAD(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADH
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1
Reaction
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References

TitleAuthorsDatePubMed ID
On the mechanism of the reaction catalyzed by glucose 6-phosphate dehydrogenase.Cosgrove MS, Naylor C, Paludan S, Adams MJ, Levy HR1998 Mar 39485426
Purification and characterization of the NAD-preferring glucose 6-phosphate dehydrogenase from Acetobacter hansenii (Acetobacter xylinum).Ragunathan S, Levy HR1994 May 18179320
Glucose 6-phosphate dehydrogenase from Leuconostoc mesenteroides. Kinetic studies.Olive C, Geroch ME, Levy HR1971 Apr 104396688
The oxidative pentose phosphate pathway in the haloarchaeon Haloferax volcanii involves a novel type of glucose-6-phosphate dehydrogenase--The archaeal Zwischenferment.Pickl A, Schönheit P2015 Apr 2825836736

RHEA:15841 D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1
Reaction
Core-to-Core More
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Cloning and characterization of the Pseudomonas aeruginosa zwf gene encoding glucose-6-phosphate dehydrogenase, an enzyme important in resistance to methyl viologen (paraquat).Ma JF, Hager PW, Howell ML, Phibbs PV, Hassett DJ1998 Apr9537370
On the mechanism of the reaction catalyzed by glucose 6-phosphate dehydrogenase.Cosgrove MS, Naylor C, Paludan S, Adams MJ, Levy HR1998 Mar 39485426
Testis-specific expression of a functional retroposon encoding glucose-6-phosphate dehydrogenase in the mouse.Hendriksen PJ, Hoogerbrugge JW, Baarends WM, de Boer P, Vreeburg JT, Vos EA, van der Lende T, Grootegoed JA1997 May 19169132
Purification and characterization of the NAD-preferring glucose 6-phosphate dehydrogenase from Acetobacter hansenii (Acetobacter xylinum).Ragunathan S, Levy HR1994 May 18179320
Glucose 6-phosphate dehydrogenase from Leuconostoc mesenteroides. Kinetic studies.Olive C, Geroch ME, Levy HR1971 Apr 104396688
Characterization of glucose-6-phosphate dehydrogenase isozymes from human and pig brain.Cho SW, Joshi JG19902270145
The cofactor preference of glucose-6-phosphate dehydrogenase from Escherichia coli--modeling the physiological production of reduced cofactors.Olavarría K, Valdés D, Cabrera R2012 Jul22519976
Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase: a unique bifunctional enzyme from Plasmodium falciparum.Jortzik E, Mailu BM, Preuss J, Fischer M, Bode L, Rahlfs S, Becker K2011 Jun 1521443518
Purification and properties of glucose 6-phosphate dehydrogenase from Aspergillus aculeatus.Ibraheem O, Adewale IO, Afolayan A2005 Sep 3016202239
Structural studies of glucose-6-phosphate and NADP+ binding to human glucose-6-phosphate dehydrogenase.Kotaka M, Gover S, Vandeputte-Rutten L, Au SW, Lam VM, Adams MJ2005 May15858258
Lysine-21 of Leuconostoc mesenteroides glucose 6-phosphate dehydrogenase participates in substrate binding through charge-charge interaction.Lee WT, Levy HR1992 Mar1304341
Glucose-6-phosphate dehydrogenase from the hyperthermophilic bacterium Thermotoga maritima: expression of the g6pd gene and characterization of an extremely thermophilic enzyme.Hansen T, Schlichting B, Schönheit P2002 Nov 512435510
Cloning, expression, and characterization of the gsdA gene encoding thermophilic glucose-6-phosphate dehydrogenase from Aquifex aeolicus.Iyer RB, Wang J, Bachas LG2002 Aug12215813
Delineation of the roles of amino acids involved in the catalytic functions of Leuconostoc mesenteroides glucose 6-phosphate dehydrogenase.Vought V, Ciccone T, Davino MH, Fairbairn L, Lin Y, Cosgrove MS, Adams MJ, Levy HR2000 Dec 1211106479
An examination of the role of asp-177 in the His-Asp catalytic dyad of Leuconostoc mesenteroides glucose 6-phosphate dehydrogenase: X-ray structure and pH dependence of kinetic parameters of the D177N mutant enzyme.Cosgrove MS, Gover S, Naylor CE, Vandeputte-Rutten L, Adams MJ, Levy HR2000 Dec 1211106478
NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase.Miclet E, Stoven V, Michels PA, Opperdoes FR, Lallemand JY, Duffieux F2001 Sep 1411457850