EC number:1.1.1.391

Enzyme

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     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.391
Description:3-beta-hydroxycholanate 3-dehydrogenase (NAD(+)).
Alternative Name: 3-beta-hydroxysteroid dehydrogenase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.391
BRENDA Enzyme Link: BRENDA 1.1.1.391
KEGG Enzyme Link: KEGG1.1.1.391
BioCyc Enzyme Link: BioCyc 1.1.1.391
ExPASy Enzyme Link: ExPASy1.1.1.391
EC2PDB Enzyme Link: EC2PDB 1.1.1.391
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.391
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.391
IntEnz Enzyme Link: IntEnz 1.1.1.391
MEDLINE Enzyme Link: MEDLINE 1.1.1.391

EC number:1.1.1.391

MSA:

1.1.1.391;
Phylogenetic Tree:

1.1.1.391;
Uniprot:
M-CSA:
RHEA:47508 3-oxo-5beta-cholan-24-oate + H(+) + NADH = isolithocholate + NAD(+)
RULE(radius=1) [*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[C;H0;+0:8](-[*:9])-[CH2;+0:10]-[CH;+0:11]=[CH;+0:12]-1.[H+;H0:13]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[c;H0;+0:8](-[*:9]):[cH;+0:10]:[cH;+0:11]:[cH;+0:12]:1
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References

TitleAuthorsDatePubMed ID
A biosynthetic pathway for a prominent class of microbiota-derived bile acids.Devlin AS, Fischbach MA2015 Sep26192599
Partial purification and characterization of an NAD-dependent 3 beta-hydroxysteroid dehydrogenase from Clostridium innocuum.Edenharder R, Pfützner M1989 Jun2764572
Characterization of NAD-dependent 3 alpha- and 3 beta-hydroxysteroid dehydrogenase and of NADP-dependent 7 beta-hydroxysteroid dehydrogenase from Peptostreptococcus productus.Edenharder R, Pfützner A, Hammann R1989 Aug 82752021